PEPD - Xaa-Pro dipeptidase - human protein (Function)
 
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PEPD »  Xaa-Pro dipeptidase   [ EC 3.4.13.9 ]  (X-Pro dipeptidase)
 
Protein also known as:  Proline dipeptidase (Prolidase).
Gene name:  PEPD
Entry whose protein(s) existence is based on evidence at protein level
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1 63 3
GENE REF ISO

Function

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Overview 
Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.  
  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177] silver  
  • IEAInterPro 2 GO
Dipeptidase activitydefinition[GO:0016805]  
  • IEAUniProtKB KW
Manganese ion bindingdefinition[GO:0030145] silver  
  • IEAInterPro 2 GO
Metallocarboxypeptidase activitydefinition[GO:0004181]  
1
  • TASPINC
GO biological process 
Cellular amino acid metabolic processdefinition[GO:0006520]  
1
  • TASPINC
Collagen catabolic processdefinition[GO:0030574]  
  • IEAUniProtKB KW
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.13.9: Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 manganese ions per subunit.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Dipeptidase  definition   [KW-0224]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PEPD
GenomeRNAi: 5184
PRO: PR:P12955