LAMP2 - Lysosome-associated membrane glycoprotein 2 - human protein (Function)
 
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LAMP2 »  Lysosome-associated membrane glycoprotein 2  (LAMP-2)
 
Protein also known as:  CD107 antigen-like family member B; CD antigen CD107b.
Gene name:  LAMP2
Family name: LAMP
Entry whose protein(s) existence is based on evidence at protein level
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1 79 3
GENE REF ISO

Function

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Overview 
Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the lysosomal protein import (lpi) family  9.A.16.1.2  
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
GO biological process 
Protein stabilizationdefinition[GO:0050821]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+3920  
Phagosome  hsa04145+3920  
Tuberculosis  hsa05152+3920  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LAMP2
GenomeRNAi: 3920
PRO: PR:P13473