BMP1 - Bone morphogenetic protein 1 - human protein (Function)
 
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BMP1 »  Bone morphogenetic protein 1   [ EC 3.4.24.19 ]  (BMP-1)
 
Protein also known as:  Mammalian tolloid protein (mTld).
Gene name:  BMP1
Family name: Peptidase M12A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 6
GENE REF ISO

Function

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Overview 
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.  
1
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Cytokine activitydefinition[GO:0005125]  
1
  • UniProtKB KW
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Metallopeptidase activitydefinition[GO:0008237]  
1
  • UniProtKB
Peptidase activitydefinition[GO:0008233]  
2
  • UniProtKB
  • MGI
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cartilage condensationdefinition[GO:0001502]  
1
  • PINC
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • PINC
Ossificationdefinition[GO:0001503]  
1
  • UniProtKB KW
Positive regulation of cartilage developmentdefinition[GO:0061036]  
1
  • MGI
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB
Skeletal system developmentdefinition[GO:0001501]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.19: Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.  
1
  • UniProtKB
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
2
  • UniProtKB
It is regulated in the following manner
Activity is increased by the procollagen C-endopeptidase enhancer protein.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Anchoring fibril formation  REACT_150268  
Collagen biosynthesis and modifying enzymes  REACT_121139  
Crosslinking of collagen fibrils  REACT_150206  
Degradation of the extracellular matrix  REACT_118572  
HDL-mediated lipid transport  REACT_13621  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Osteogenesis  definition   [KW-0892]
Molecular function 
Cytokine  definition   [KW-0202]
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links