BMP1 - Bone morphogenetic protein 1 - human protein (Function)
 
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BMP1 »  Bone morphogenetic protein 1   [ EC 3.4.24.19 ]  (BMP-1)
 
Protein also known as:  Mammalian tolloid protein (mTld).
Gene name:  BMP1
Family name: Peptidase M12A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 6
GENE REF ISO

Function

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Overview 
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Metallopeptidase activitydefinition[GO:0008237]  
1
  • NASUniProtKB
Peptidase activitydefinition[GO:0008233]  
2
  • IDAUniProtKB
  • IDAMGI
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cartilage condensationdefinition[GO:0001502]  
1
  • TASPINC
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Ossificationdefinition[GO:0001503]  
  • IEAUniProtKB KW
Positive regulation of cartilage developmentdefinition[GO:0061036]  
1
  • IDAMGI
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Skeletal system developmentdefinition[GO:0001501]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.19: Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activity is increased by the procollagen C-endopeptidase enhancer protein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Osteogenesis  definition   [KW-0892]
Molecular function 
Cytokine  definition   [KW-0202]
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links