CYBA - Cytochrome b-245 light chain - human protein (Function)
 
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CYBA »  Cytochrome b-245 light chain
 
Protein also known as:  Superoxide-generating NADPH oxidase light chain subunit.
Gene name:  CYBA
Family name: P22phox
Entry whose protein(s) existence is based on evidence at protein level
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1 146 1
GENE REF ISO

Function

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Overview 
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the phagocyte (gp91(phox)) nadph oxidase family  5.B.1.1.1  
GO molecular function 
Electron carrier activitydefinition[GO:0009055]  
2
  • IDABHF-UCL
  • TASUniProtKB
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
SH3 domain bindingdefinition[GO:0017124]  
1
  • IPIBHF-UCL
Contributes to superoxide-generating NADPH oxidase activitydefinition[GO:0016175]  
1
  • IMPBHF-UCL
GO biological process 
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Cellular response to gamma radiationdefinition[GO:0071480] silver  
  • IEAOrtholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
  • IEAOrtholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Cytochrome complex assemblydefinition[GO:0017004]  
1
  • IDABHF-UCL
Hydrogen peroxide biosynthetic processdefinition[GO:0050665]  
  • ISSOrtholog Curator
Inflammatory responsedefinition[GO:0006954]  
1
  • IMPBHF-UCL
Innate immune responsedefinition[GO:0045087]  
1
  • IMPBHF-UCL
Negative regulation of glomerular filtration by angiotensindefinition[GO:0003106] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
2
  • IMPBHF-UCL
Positive regulation of cell growthdefinition[GO:0030307] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell proliferationdefinition[GO:0001938] silver  
  • IEAOrtholog Compara
Respiratory burstdefinition[GO:0045730]  
1
  • IMPBHF-UCL
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to interleukin-1definition[GO:0070555] silver  
  • IEAOrtholog Compara
Response to nutrient levelsdefinition[GO:0031667] silver  
  • IEAOrtholog Compara
Smooth muscle hypertrophydefinition[GO:0014895]  
  • ISSOrtholog Curator
Superoxide anion generationdefinition[GO:0042554]  
1
  • IMPBHF-UCL
Superoxide metabolic processdefinition[GO:0006801]  
2
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Leishmaniasis  hsa05140+1535  
Leukocyte transendothelial migration  hsa04670+1535  
Osteoclast differentiation  hsa04380+1535  
Phagosome  hsa04145+1535  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Transport  definition   [KW-0813]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1535
PRO: PR:P13498