MYH6 - Myosin-6 - human protein (Function)
 
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MYH6 »  Myosin-6
 
Protein also known as:  Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).
Gene name:  MYH6
Entry whose protein(s) existence is based on evidence at protein level
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1 51 1
GENE REF ISO

Function

 show evidences
Overview 
Muscle contraction.  
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
Actin-dependent ATPase activitydefinition[GO:0030898]  
1
  • IMPHGNC
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activitydefinition[GO:0016887]  
1
  • IDAHGNC
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Microfilament motor activitydefinition[GO:0000146]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Protein kinase bindingdefinition[GO:0019901]  
2
  • IPIUniProtKB
GO biological process 
Adult heart developmentdefinition[GO:0007512]  
2
  • IMPHGNC
ATP catabolic processdefinition[GO:0006200]  
1
  • IMPBHF-UCL
Atrial cardiac muscle tissue morphogenesisdefinition[GO:0055009]  
1
  • IMPHGNC
BMP signaling pathwaydefinition[GO:0030509] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Cardiac muscle fiber developmentdefinition[GO:0048739]  
  • ISSOrtholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
  • ISSOrtholog Curator
Muscle contractiondefinition[GO:0006936]  
1
  • IDAHGNC
Muscle filament slidingdefinition[GO:0030049]  
1
  • IMPHGNC
Myofibril assemblydefinition[GO:0030239]  
  • ISSOrtholog Curator
Regulation of ATPase activitydefinition[GO:0043462]  
  • ISSOrtholog Curator
Regulation of blood pressuredefinition[GO:0008217]  
  • ISSOrtholog Curator
Regulation of heart contractiondefinition[GO:0008016]  
  • ISSOrtholog Curator
Regulation of heart growthdefinition[GO:0060420] silver  
  • IEAOrtholog Compara
Regulation of heart ratedefinition[GO:0002027]  
1
  • IDAHGNC
Regulation of the force of heart contractiondefinition[GO:0002026]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Sarcomere organizationdefinition[GO:0045214]  
  • ISSOrtholog Curator
Striated muscle contractiondefinition[GO:0006941]  
1
  • IMPBHF-UCL
  • ISSOrtholog Curator
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
2
  • IMPHGNC
Visceral muscle developmentdefinition[GO:0007522]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cardiac muscle contraction  hsa04260+4624  
Dilated cardiomyopathy  hsa05414+4624  
Hypertrophic cardiomyopathy (HCM)  hsa05410+4624  
Tight junction  hsa04530+4624  
Viral myocarditis  hsa05416+4624  
According to Reactome, this protein belongs to the following pathways:
Membrane Trafficking  REACT_11123  
Muscle contraction  REACT_17044  
Note 
The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.  
  • CuratedUniProtKB
Caution 
Represents a conventional myosin. This protein should not be confused with the unconventional myosin-6 (MYO6).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Motor protein  definition   [KW-0505]
Muscle protein  definition   [KW-0514]
Myosin  definition   [KW-0518]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYH6
GenomeRNAi: 4624
PRO: PR:P13533