CFTR - Cystic fibrosis transmembrane conductance regulator - human protein (Function)
 
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Protein
Gene
References

 
CFTR »  Cystic fibrosis transmembrane conductance regulator
 
Gene name:  CFTR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 870 3
GENE REF ISO

Function

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Overview 
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.202.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATP-binding and phosphorylation-dependent chloride channel activitydefinition[GO:0005224]  
1
  • TASPINC
Bicarbonate transmembrane transporter activitydefinition[GO:0015106]  
  • ISSOrtholog Curator
Channel-conductance-controlling ATPase activitydefinition[GO:0005260]  
1
  • NASUniProtKB
Chloride channel activitydefinition[GO:0005254]  
1
  • IDAUniProtKB
Chloride channel inhibitor activitydefinition[GO:0019869]  
1
  • IDAUniProtKB
Chloride transmembrane transporter activitydefinition[GO:0015108]  
  • ISSOrtholog Curator
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
PDZ domain bindingdefinition[GO:0030165]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
19
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Bicarbonate transportdefinition[GO:0015701] silver  
  • IEAOrtholog Compara
Cellular response to cAMPdefinition[GO:0071320]  
  • ISSOrtholog Curator
Cellular response to hormone stimulusdefinition[GO:0032870] silver  
  • IEAOrtholog Compara
Chloride transmembrane transportdefinition[GO:1902476]  
4
  • IDAGOC
  • IEAInterPro 2 GO
  • IEAUniProtKB KW
  • IEAOrtholog Compara
  • ISSOrtholog Curator
  • IEAEC 2 GO
Cholesterol biosynthetic processdefinition[GO:0006695] silver  
  • IEAOrtholog Compara
Cholesterol transportdefinition[GO:0030301] silver  
  • IEAOrtholog Compara
Intracellular pH elevationdefinition[GO:0051454]  
  • ISSOrtholog Curator
Iodide transportdefinition[GO:0015705] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Membrane hyperpolarizationdefinition[GO:0060081]  
  • ISSOrtholog Curator
Positive regulation of vasodilationdefinition[GO:0045909] silver  
  • IEAOrtholog Compara
Positive regulation of voltage-gated chloride channel activitydefinition[GO:1902943]  
1
  • IDAUniProtKB
Respiratory gaseous exchangedefinition[GO:0007585]  
1
  • TASPINC
Response to cytokinedefinition[GO:0034097] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Sperm capacitationdefinition[GO:0048240]  
  • ISSOrtholog Curator
Transepithelial chloride transportdefinition[GO:0030321] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
2
  • TASPINC
Vasodilationdefinition[GO:0042311] silver  
  • IEAOrtholog Compara
Water transportdefinition[GO:0006833] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.49: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+1080  
Bile secretion  hsa04976+1080  
Gastric acid secretion  hsa04971+1080  
Pancreatic secretion  hsa04972+1080  
Vibrio cholerae infection  hsa05110+1080  
According to Reactome, this protein belongs to the following pathway:
ABC-family proteins mediated transport  REACT_15480  
 
More information is available from:
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Hydrolase  definition   [KW-0378]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 1080
PRO: PR:P13569
Chemistry
GuidetoPHARMACOLOGY: 707