CFTR - Cystic fibrosis transmembrane conductance regulator - human protein (Function)
 
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Protein
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CFTR »  Cystic fibrosis transmembrane conductance regulator  (CFTR)
 
Protein also known as:  ATP-binding cassette sub-family C member 7.
Gene name:  CFTR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 896 3
GENE REF ISO

Function

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Overview 
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.202.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATP-binding and phosphorylation-dependent chloride channel activitydefinition[GO:0005224]  
1
  • PINC
Bicarbonate transmembrane transporter activitydefinition[GO:0015106]  
1
  • Ortholog Curator
Channel-conductance-controlling ATPase activitydefinition[GO:0005260]  
1
  • UniProtKB
Chloride channel activitydefinition[GO:0005254]  
2
  • UniProtKB
Chloride channel inhibitor activitydefinition[GO:0019869]  
1
  • UniProtKB
Chloride transmembrane transporter activitydefinition[GO:0015108]  
1
  • Ortholog Curator
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
PDZ domain bindingdefinition[GO:0030165]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
19
  • IntAct
  • UniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • InterPro 2 GO
Bicarbonate transportdefinition[GO:0015701] silver  
1
  • Ortholog Compara
Cellular response to cAMPdefinition[GO:0071320]  
1
  • Ortholog Curator
Cellular response to hormone stimulusdefinition[GO:0032870] silver  
1
  • Ortholog Compara
Chloride transmembrane transportdefinition[GO:1902476]  
10
  • GOC
  • UniProtKB KW
  • EC 2 GO
  • InterPro 2 GO
  • Ortholog Curator
  • Ortholog Compara
Cholesterol biosynthetic processdefinition[GO:0006695] silver  
1
  • Ortholog Compara
Cholesterol transportdefinition[GO:0030301] silver  
1
  • Ortholog Compara
Intracellular pH elevationdefinition[GO:0051454]  
1
  • Ortholog Curator
Iodide transportdefinition[GO:0015705] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Membrane hyperpolarizationdefinition[GO:0060081]  
1
  • Ortholog Curator
Positive regulation of vasodilationdefinition[GO:0045909] silver  
1
  • Ortholog Compara
Positive regulation of voltage-gated chloride channel activitydefinition[GO:1902943]  
1
  • UniProtKB
Respiratory gaseous exchangedefinition[GO:0007585]  
1
  • PINC
Response to cytokinedefinition[GO:0034097] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
1
  • Ortholog Compara
Sperm capacitationdefinition[GO:0048240]  
1
  • Ortholog Curator
Transepithelial chloride transportdefinition[GO:0030321] silver  
1
  • Ortholog Compara
Transportdefinition[GO:0006810]  
2
  • PINC
Vasodilationdefinition[GO:0042311] silver  
1
  • Ortholog Compara
Water transportdefinition[GO:0006833] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.49: ATP + H(2)O ADP + phosphate.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+1080  
Bile secretion  hsa04976+1080  
Gastric acid secretion  hsa04971+1080  
Pancreatic secretion  hsa04972+1080  
Vibrio cholerae infection  hsa05110+1080  
According to Reactome, this protein belongs to the following pathway:
ABC-family proteins mediated transport  REACT_15480  
 
More information is available from:
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Hydrolase  definition   [KW-0378]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 1080
PRO: PR:P13569
Protein family/group databases
MoonProt: P13569
Chemistry
GuidetoPHARMACOLOGY: 707