CFTR - Cystic fibrosis transmembrane conductance regulator - human protein (Function)
 
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Protein
Gene
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CFTR »  Cystic fibrosis transmembrane conductance regulator  (CFTR)
 
Protein also known as:  ATP-binding cassette sub-family C member 7.
Gene name:  CFTR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 965 3
GENE REF ISO

Function

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Overview 
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.202.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATP-binding and phosphorylation-dependent chloride channel activitydefinition[GO:0005224]  
1
  • PINC
Bicarbonate transmembrane transporter activitydefinition[GO:0015106]  
1
  • Ortholog Curator
Channel-conductance-controlling ATPase activitydefinition[GO:0005260]  
1
  • UniProtKB
Chloride channel activitydefinition[GO:0005254]  
3
  • UniProtKB
Chloride channel inhibitor activitydefinition[GO:0019869]  
1
  • UniProtKB
Chloride transmembrane transporter activitydefinition[GO:0015108]  
1
  • Ortholog Curator
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
PDZ domain bindingdefinition[GO:0030165]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
19
  • IntAct
  • UniProtKB
GO biological process 
Bicarbonate transportdefinition[GO:0015701]  
2
  • Ortholog Compara
  • Ortholog Curator
Cellular response to cAMPdefinition[GO:0071320]  
1
  • Ortholog Curator
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • UniProtKB
Cholesterol biosynthetic processdefinition[GO:0006695] silver  
1
  • Ortholog Compara
Cholesterol transportdefinition[GO:0030301] silver  
1
  • Ortholog Compara
Intracellular pH elevationdefinition[GO:0051454]  
1
  • Ortholog Curator
Membrane hyperpolarizationdefinition[GO:0060081]  
1
  • Ortholog Curator
Positive regulation of cyclic nucleotide-gated ion channel activitydefinition[GO:1902161]  
1
  • UniProtKB
Positive regulation of exocytosisdefinition[GO:0045921]  
1
  • UniProtKB
Positive regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0035774]  
2
  • UniProtKB
Positive regulation of voltage-gated chloride channel activitydefinition[GO:1902943]  
1
  • UniProtKB
Respiratory gaseous exchangedefinition[GO:0007585]  
1
  • PINC
Sperm capacitationdefinition[GO:0048240]  
1
  • Ortholog Curator
Transportdefinition[GO:0006810]  
2
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.49: ATP + H(2)O ADP + phosphate.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+1080  
Bile secretion  hsa04976+1080  
Gastric acid secretion  hsa04971+1080  
Pancreatic secretion  hsa04972+1080  
Vibrio cholerae infection  hsa05110+1080  
According to Reactome, this protein belongs to the following pathways:
ABC-family proteins mediated transport  R-HSA-382556  
Defective CFTR causes cystic fibrosis  R-HSA-5678895  
RHO GTPases regulate CFTR trafficking  R-HSA-5627083  
 
More information is available from:
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Hydrolase  definition   [KW-0378]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 1080
PRO: PR:P13569
Protein family/group databases
MoonProt: P13569
Chemistry
GuidetoPHARMACOLOGY: 707