ICAM2 - Intercellular adhesion molecule 2 - human protein (Function)
 
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ICAM2 »  Intercellular adhesion molecule 2  (ICAM-2)
 
Protein also known as:  CD antigen CD102.
Gene name:  ICAM2
Family name: Immunoglobulin » ICAM
Entry whose protein(s) existence is based on evidence at protein level
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1 37 1
GENE REF ISO

Function

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Overview 
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.  
  • CuratedUniProtKB
GO molecular function 
Integrin bindingdefinition[GO:0005178]  
1
  • IPIBHF-UCL
GO biological process 
Single organismal cell-cell adhesiondefinition[GO:0016337] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+3384  
Natural killer cell mediated cytotoxicity  hsa04650+3384  
According to Reactome, this protein belongs to the following pathways:
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell  REACT_11152  
Integrin cell surface interactions  REACT_13552  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ICAM2
GenomeRNAi: 3384
PRO: PR:P13598