ATP1A3 - Sodium/potassium-transporting ATPase subunit alpha-3 - human protein (Function)
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ATP1A3 »  Sodium/potassium-transporting ATPase subunit alpha-3   [ EC ]  (Na(+)/K(+) ATPase alpha-3 subunit)
Protein also known as:  Na(+)/K(+) ATPase alpha(III) subunit.
Gene name:  ATP1A3
Entry whose protein(s) existence is based on evidence at protein level
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This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.1.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • NASUniProtKB
D1 dopamine receptor bindingdefinition[GO:0031748] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Sodium:potassium-exchanging ATPase activitydefinition[GO:0005391]  
  • IMPUniProtKB
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
ATP biosynthetic processdefinition[GO:0006754] silver  
  • IEAInterPro 2 GO
Ionotropic glutamate receptor signaling pathwaydefinition[GO:0035235] silver  
  • IEAOrtholog Compara
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
  • IEAEC 2 GO
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + H(2)O + Na(+)(In) + K(+)(Out) ADP + phosphate + Na(+)(Out) + K(+)(In).  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+478  
Bile secretion  hsa04976+478  
Carbohydrate digestion and absorption  hsa04973+478  
Cardiac muscle contraction  hsa04260+478  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+478  
Gastric acid secretion  hsa04971+478  
Mineral absorption  hsa04978+478  
Pancreatic secretion  hsa04972+478  
Protein digestion and absorption  hsa04974+478  
Proximal tubule bicarbonate reclamation  hsa04964+478  
Salivary secretion  hsa04970+478  
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  


Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Sodium/potassium transport  definition   [KW-0740]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: ATP1A3
GenomeRNAi: 478
PRO: PR:P13637