ATP1A3 - Sodium/potassium-transporting ATPase subunit alpha-3 - human protein (Function)
 
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ATP1A3 »  Sodium/potassium-transporting ATPase subunit alpha-3   [ EC 3.6.3.9 ]  (Na(+)/K(+) ATPase alpha-3 subunit)
 
Protein also known as:  Na(+)/K(+) ATPase alpha(III) subunit.
Gene name:  ATP1A3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.1.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Chaperone bindingdefinition[GO:0051087]  
1
  • BHF-UCL
D1 dopamine receptor bindingdefinition[GO:0031748] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Sodium:potassium-exchanging ATPase activitydefinition[GO:0005391]  
2
  • UniProtKB
  • BHF-UCL
Steroid hormone bindingdefinition[GO:1990239]  
1
  • BHF-UCL
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
ATP biosynthetic processdefinition[GO:0006754] silver  
1
  • InterPro 2 GO
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
1
  • BHF-UCL
Cellular potassium ion homeostasisdefinition[GO:0030007]  
1
  • BHF-UCL
Cellular response to steroid hormone stimulusdefinition[GO:0071383]  
1
  • BHF-UCL
Cellular sodium ion homeostasisdefinition[GO:0006883]  
1
  • BHF-UCL
Ionotropic glutamate receptor signaling pathwaydefinition[GO:0035235] silver  
1
  • Ortholog Compara
Memorydefinition[GO:0007613] silver  
1
  • Ortholog Compara
Potassium ion importdefinition[GO:0010107]  
1
  • BHF-UCL
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to glycosidedefinition[GO:1903416]  
1
  • BHF-UCL
Sodium ion export from celldefinition[GO:0036376]  
1
  • BHF-UCL
Visual learningdefinition[GO:0008542] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.9: ATP + H(2)O + Na(+)(In) + K(+)(Out) ADP + phosphate + Na(+)(Out) + K(+)(In).  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+478  
Bile secretion  hsa04976+478  
Carbohydrate digestion and absorption  hsa04973+478  
Cardiac muscle contraction  hsa04260+478  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+478  
Gastric acid secretion  hsa04971+478  
Mineral absorption  hsa04978+478  
Pancreatic secretion  hsa04972+478  
Protein digestion and absorption  hsa04974+478  
Proximal tubule bicarbonate reclamation  hsa04964+478  
Salivary secretion  hsa04970+478  
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Sodium/potassium transport  definition   [KW-0740]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP1A3
GenomeRNAi: 478
PRO: PR:P13637