P4HA1 - Prolyl 4-hydroxylase subunit alpha-1 - human protein (Function)
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P4HA1 »  Prolyl 4-hydroxylase subunit alpha-1   [ EC ]  (4-PH alpha-1)
Protein also known as:  Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1.
Gene name:  P4HA1
Family name: P4HA
Entry whose protein(s) existence is based on evidence at protein level
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Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.  
  • CuratedUniProtKB
GO molecular function 
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
L-ascorbic acid bindingdefinition[GO:0031418]  
  • IEAUniProtKB KW
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygendefinition[GO:0016702] silver  
  • IEAInterPro 2 GO
Procollagen-proline 4-dioxygenase activitydefinition[GO:0004656]  
  • IEAEC 2 GO
GO biological process 
Collagen fibril organizationdefinition[GO:0030199] silver  
  • IEAOrtholog Compara
Peptidyl-proline hydroxylation to 4-hydroxy-L-prolinedefinition[GO:0018401] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC L-proline-[procollagen] + 2-oxoglutarate + O(2) trans-4-hydroxy-L-proline-[procollagen] + succinate + CO(2).  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 Fe(2+) ion per subunit.  
  • CuratedUniProtKB
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+5033  
Metabolic pathways  hsa01100+5033  


Molecular function 
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: P4HA1
GenomeRNAi: 5033
PRO: PR:P13674