ACP5 - Tartrate-resistant acid phosphatase type 5 - human protein (Function)
 
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ACP5 »  Tartrate-resistant acid phosphatase type 5   [ EC 3.1.3.2 ]  (TR-AP)
 
Protein also known as:  Tartrate-resistant acid ATPase (TrATPase).
Gene name:  ACP5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.  
  • CuratedUniProtKB
GO molecular function 
Ferric iron bindingdefinition[GO:0008199]  
1
  • IDAUniProtKB
Ferrous iron bindingdefinition[GO:0008198]  
1
  • IDAUniProtKB
GO biological process 
Bone morphogenesisdefinition[GO:0060349] silver  
  • IEAOrtholog Compara
Bone resorptiondefinition[GO:0045453] silver  
  • IEAOrtholog Compara
Defense response to Gram-positive bacteriumdefinition[GO:0050830] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-1 beta productiondefinition[GO:0032691] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-12 productiondefinition[GO:0032695] silver  
  • IEAOrtholog Compara
Negative regulation of nitric oxide biosynthetic processdefinition[GO:0045019] silver  
  • IEAOrtholog Compara
Negative regulation of superoxide anion generationdefinition[GO:0032929] silver  
  • IEAOrtholog Compara
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720] silver  
  • IEAOrtholog Compara
Response to cytokinedefinition[GO:0034097] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.2: A phosphate monoester + H(2)O an alcohol + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 iron ions per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+54  
Osteoclast differentiation  hsa04380+54  
Rheumatoid arthritis  hsa05323+54  
Riboflavin metabolism  hsa00740+54  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P13686
Other
GeneWiki: Tartrate-resistant_acid_phosphatase
GenomeRNAi: 54
PRO: PR:P13686