F3 - Tissue factor - human protein (Function)
 
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F3 »  Tissue factor  (TF)
 
Protein also known as:  Coagulation factor III; CD antigen CD142.
Gene name:  F3
Family name: Tissue factor
Entry whose protein(s) existence is based on evidence at protein level
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1 439 2
GENE REF ISO

Function

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Overview 
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.  
1
  • CuratedUniProtKB
GO molecular function 
Phospholipid bindingdefinition[GO:0005543]  
1
  • IDABHF-UCL
Protease bindingdefinition[GO:0002020]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Activation of blood coagulation via clotting cascadedefinition[GO:0002543]  
1
  • ICBHF-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IDABHF-UCL
Activation of plasma proteins involved in acute inflammatory responsedefinition[GO:0002541]  
1
  • IDABHF-UCL
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IDABHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • TASBHF-UCL
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IDABHF-UCL
Positive regulation of platelet-derived growth factor receptor signaling pathwaydefinition[GO:0010641]  
1
  • IDABHF-UCL
Positive regulation of positive chemotaxisdefinition[GO:0050927]  
1
  • ICBHF-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Complement and coagulation cascades  hsa04610+2152  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Tissue_factor
GenomeRNAi: 2152
PRO: PR:P13726