HLA-DOB - HLA class II histocompatibility antigen, DO beta chain - human protein (Function)
 
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HLA-DOB »  HLA class II histocompatibility antigen, DO beta chain
 
Protein also known as:  MHC class II antigen DOB.
Gene name:  HLA-DOB
Family name: MHC class II
Entry whose protein(s) existence is based on evidence at protein level
extend overview
6 24 1
GENE REF ISO

Function

 show evidences
Overview 
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.  
  • CuratedUniProtKB
GO molecular function 
MHC class II receptor activitydefinition[GO:0032395]  
1
  • TASUniProtKB
GO biological process 
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Allograft rejection  hsa05330+3112  
Antigen processing and presentation  hsa04612+3112  
Asthma  hsa05310+3112  
Autoimmune thyroid disease  hsa05320+3112  
Cell adhesion molecules (CAMs)  hsa04514+3112  
Graft-versus-host disease  hsa05332+3112  
Herpes simplex infection  hsa05168+3112  
HTLV-I infection  hsa05166+3112  
Influenza A  hsa05164+3112  
Intestinal immune network for IgA production  hsa04672+3112  
Leishmaniasis  hsa05140+3112  
Phagosome  hsa04145+3112  
Rheumatoid arthritis  hsa05323+3112  
Staphylococcus aureus infection  hsa05150+3112  
Systemic lupus erythematosus  hsa05322+3112  
Toxoplasmosis  hsa05145+3112  
Tuberculosis  hsa05152+3112  
Type I diabetes mellitus  hsa04940+3112  
Viral myocarditis  hsa05416+3112  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HLA-DOB
GenomeRNAi: 3112
PRO: PR:P13765