APEH - Acylamino-acid-releasing enzyme - human protein (Function)
 
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APEH »  Acylamino-acid-releasing enzyme   [ EC 3.4.19.1 ]  (AARE)
 
Protein also known as:  Oxidized protein hydrolase (OPH).
Gene name:  APEH
Family name: Peptidase S9C
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.  
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  • CuratedUniProtKB
GO molecular function 
Omega peptidase activitydefinition[GO:0008242]  
1
  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252]  
1
  • IDAUniProtKB
GO biological process 
Beta-amyloid metabolic processdefinition[GO:0050435]  
1
  • IDAUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.1: Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: APEH_(gene)
GenomeRNAi: 327
PRO: PR:P13798