ADRB3 - Beta-3 adrenergic receptor - human protein (Function)
 
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ADRB3 »  Beta-3 adrenergic receptor
 
Protein also known as:  Beta-3 adrenoreceptor (Beta-3 adrenoceptor).
Gene name:  ADRB3
Entry whose protein(s) existence is based on evidence at transcript level
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1 119 1
GENE REF ISO

Function

 show evidences
Overview 
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.  
  • CuratedUniProtKB
GO molecular function 
Beta-3 adrenergic receptor bindingdefinition[GO:0031699] silver  
  • IEAOrtholog Compara
Beta-adrenergic receptor activitydefinition[GO:0004939]  
1
  • IDAHGNC
Beta3-adrenergic receptor activitydefinition[GO:0015052]  
1
  • IMPHGNC
Epinephrine bindingdefinition[GO:0051379] silver  
  • IEAOrtholog Compara
Contributes to norepinephrine bindingdefinition[GO:0051380]  
1
  • IDAHGNC
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAHGNC
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • IDAHGNC
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
  • IEAOrtholog Compara
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • TASPINC
Adrenergic receptor signaling pathwaydefinition[GO:0071875]  
2
  • IDAGOC
  • IEAInterPro 2 GO
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Brown fat cell differentiationdefinition[GO:0050873] silver  
  • IEAOrtholog Compara
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • TASPINC
Not  Desensitization of G-protein coupled receptor protein signaling pathway by arrestindefinition[GO:0002032]  
1
  • IDAHGNC
Diet induced thermogenesisdefinition[GO:0002024] silver  
  • IEAOrtholog Compara
Eating behaviordefinition[GO:0042755] silver  
  • IEAOrtholog Compara
Energy reserve metabolic processdefinition[GO:0006112]  
1
  • TASPINC
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Heat generationdefinition[GO:0031649] silver  
  • IEAOrtholog Compara
Negative regulation of multicellular organism growthdefinition[GO:0040015] silver  
  • IEAOrtholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IDAHGNC
Not  Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • IDAHGNC
Response to antibioticdefinition[GO:0046677] silver  
  • IEAOrtholog Compara
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressuredefinition[GO:0002025] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+155  
Endocytosis  hsa04144+155  
Neuroactive ligand-receptor interaction  hsa04080+155  
Salivary secretion  hsa04970+155  
According to Reactome, this protein belongs to the following pathways:
Adrenoceptors  REACT_16927  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Beta-3_adrenergic_receptor
GenomeRNAi: 155
PRO: PR:P13945
Chemistry
GuidetoPHARMACOLOGY: 30