CD59 - CD59 glycoprotein - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CD59 »  CD59 glycoprotein
 
Protein also known as:  Membrane attack complex inhibition factor (MACIF); CD antigen CD59.
Gene name:  CD59
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 117 1
GENE REF ISO

Function

 show evidences
Overview 
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.  
  • CuratedUniProtKB
The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.  
  • CuratedUniProtKB
GO molecular function 
Complement bindingdefinition[GO:0001848] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Blood coagulationdefinition[GO:0007596]  
1
  • TASPINC
Cell activationdefinition[GO:0001775] silver  
  • IBARefGenome
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Negative regulation of activation of membrane attack complexdefinition[GO:0001971] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+966  
Hematopoietic cell lineage  hsa04640+966  
According to Reactome, this protein belongs to the following pathway:
Regulation of Complement cascade  REACT_118707  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD59
GenomeRNAi: 966
PRO: PR:P13987