CTSE - Cathepsin E - human protein (Function)
 
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CTSE »  Cathepsin E   [ EC 3.4.23.34 ]
 
Cleaved into:  Cathepsin E form I; Cathepsin E form II.
Gene name:  CTSE
Family name: Peptidase A1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 3
GENE REF ISO

Function

 show evidences
Overview 
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.  
1
  • CuratedUniProtKB
GO molecular function 
Aspartic-type endopeptidase activitydefinition[GO:0004190]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Antigen processing and presentation of exogenous peptide antigen via MHC class IIdefinition[GO:0019886]  
1
  • IDAUniProtKB
Digestiondefinition[GO:0007586]  
1
  • TASPINC
Protein autoprocessingdefinition[GO:0016540] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.23.34: Similar to cathepsin D, but slightly broader specificity.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+1510  
According to Reactome, this protein belongs to the following pathway:
MHC class II antigen presentation  REACT_121399  
 

Biophysicochemical properties

Kinetic parameters
KM 0.13 mM for Pro-Pro-Thr-Ile-Phe-Phe(4-NO2)-Arg-Leu
KM 0.06 mM for hemoglobin
KM 0.04 mM for Lys-Pro-Ile-Glu-Phe-Phe(4-NO2)-Arg-Leu

Keywords

Molecular function 
Aspartyl protease  definition   [KW-0064]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P14091
Other
GeneWiki: Cathepsin_E
GenomeRNAi: 1510
PRO: PR:P14091
Chemistry
GuidetoPHARMACOLOGY: 2346