EDN3 - Endothelin-3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
EDN3 »  Endothelin-3  (ET-3)
 
Protein also known as:  Preproendothelin-3 (PPET3).
Gene name:  EDN3
Family name: Endothelin/sarafotoxin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 54 3
GENE REF ISO

Function

 show evidences
Overview 
Endothelins are endothelium-derived vasoconstrictor peptides.  
  • CuratedUniProtKB
GO molecular function 
Hormone activitydefinition[GO:0005179]  
2
  • IDABHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • TASPINC
GO biological process 
Not  Artery smooth muscle contractiondefinition[GO:0014824]  
1
  • IDABHF-UCL
Blood circulationdefinition[GO:0008015]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • IDABHF-UCL
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Inositol phosphate-mediated signalingdefinition[GO:0048016]  
1
  • IDABHF-UCL
Melanocyte differentiationdefinition[GO:0030318] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Neural crest cell migrationdefinition[GO:0001755] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
  • IEAOrtholog Compara
Neutrophil chemotaxisdefinition[GO:0030593]  
1
  • IDABHF-UCL
Peptide hormone secretiondefinition[GO:0030072]  
1
  • IDABHF-UCL
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of heart ratedefinition[GO:0010460]  
1
  • IDABHF-UCL
Positive regulation of hormone secretiondefinition[GO:0046887]  
1
  • IDABHF-UCL
Positive regulation of leukocyte chemotaxisdefinition[GO:0002690]  
1
  • IDABHF-UCL
Positive regulation of MAP kinase activitydefinition[GO:0043406]  
1
  • IDABHF-UCL
Positive regulation of mitosisdefinition[GO:0045840]  
1
  • IDABHF-UCL
Regulation of developmental pigmentationdefinition[GO:0048070] silver  
  • IEAOrtholog Compara
Regulation of systemic arterial blood pressure by endothelindefinition[GO:0003100]  
1
  • IDABHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
  • IEAInterPro 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Vasoconstrictiondefinition[GO:0042310]  
2
  • IDABHF-UCL
Vein smooth muscle contractiondefinition[GO:0014826]  
1
  • IDABHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
Vasoactive  definition   [KW-0838]
Vasoconstrictor  definition   [KW-0839]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Endothelin_3
GenomeRNAi: 1908
PRO: PR:P14138