PRF1 - Perforin-1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PRF1 »  Perforin-1  (P1)
 
Protein also known as:  Lymphocyte pore-forming protein (PFP).
Gene name:  PRF1
Family name: Complement C6/C7/C8/C9
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 130 1
GENE REF ISO

Function

 show evidences
Overview 
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. In transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.  
6
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Wide pore channel activitydefinition[GO:0022829]  
1
  • IDAUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Cytolysisdefinition[GO:0019835]  
  • ISSOrtholog Curator
Defense response to tumor celldefinition[GO:0002357]  
  • ISSOrtholog Curator
Defense response to virusdefinition[GO:0051607]  
  • ISSOrtholog Curator
Immune response to tumor celldefinition[GO:0002418]  
  • ISSOrtholog Curator
Protein homooligomerizationdefinition[GO:0051260]  
1
  • IDAUniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • IDAGOC
Transportdefinition[GO:0006810]  
1
  • IDAGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Allograft rejection  hsa05330+5551  
Autoimmune thyroid disease  hsa05320+5551  
Graft-versus-host disease  hsa05332+5551  
Natural killer cell mediated cytotoxicity  hsa04650+5551  
Type I diabetes mellitus  hsa04940+5551  
Viral myocarditis  hsa05416+5551  
 

Keywords

Biological process 
Cytolysis  definition   [KW-0204]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Perforin
GenomeRNAi: 5551
PRO: PR:P14222