IRF2 - Interferon regulatory factor 2 - human protein (Function)
 
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IRF2 »  Interferon regulatory factor 2  (IRF-2)
 
Gene name:  IRF2
Family name: IRF
Entry whose protein(s) existence is based on evidence at protein level
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1 49 2
GENE REF ISO

Function

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Overview 
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.  
5
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
  • UniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • NTNU_SB
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228]  
1
  • NTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • UniProtKB
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • PINC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • NTNU_SB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Factors involved in megakaryocyte development and platelet production  REACT_24970  
Interferon alpha/beta signaling  REACT_25162  
Interferon gamma signaling  REACT_25078  
TRAF6 mediated IRF7 activation  REACT_24938  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IRF2
GenomeRNAi: 3660
PRO: PR:P14316