IRF2 - Interferon regulatory factor 2 - human protein (Function)
 
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IRF2 »  Interferon regulatory factor 2  (IRF-2)
 
Gene name:  IRF2
Family name: IRF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 46 2
GENE REF ISO

Function

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Overview 
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.  
4
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Regulatory region DNA bindingdefinition[GO:0000975] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IMPUniProtKB
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • TASPINC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IMPUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Immune System  REACT_6900  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IRF2
GenomeRNAi: 3660
PRO: PR:P14316