DRD2 - D(2) dopamine receptor - human protein (Function)
 
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DRD2 »  D(2) dopamine receptor
 
Protein also known as:  Dopamine D2 receptor.
Gene name:  DRD2
Entry whose protein(s) existence is based on evidence at protein level
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1 494 3
GENE REF ISO

Function

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Overview 
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
Adrenergic receptor activitydefinition[GO:0004935] silver  
  • IEAInterPro 2 GO
Dopamine bindingdefinition[GO:0035240] silver  
  • IEAOrtholog Compara
Dopamine neurotransmitter receptor activity, coupled via Gi/Godefinition[GO:0001591]  
2
  • IDABHF-UCL
Drug bindingdefinition[GO:0008144]  
1
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Ionotropic glutamate receptor bindingdefinition[GO:0035255] silver  
  • IEAOrtholog Compara
Isoform  Iso 1   Potassium channel regulator activitydefinition[GO:0015459]  
1
  • NASBHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147] silver  
  • IEAOrtholog Compara
Adenohypophysis developmentdefinition[GO:0021984]  
  • ISSOrtholog Curator
Adenylate cyclase-inhibiting dopamine receptor signaling pathwaydefinition[GO:0007195]  
2
  • IDABHF-UCL
  • IEAOrtholog Compara
Adult walking behaviordefinition[GO:0007628]  
  • ISSOrtholog Curator
Arachidonic acid secretiondefinition[GO:0050482]  
1
  • IDABHF-UCL
Associative learningdefinition[GO:0008306]  
  • ISSOrtholog Curator
Auditory behaviordefinition[GO:0031223] silver  
  • IEAOrtholog Compara
Axonogenesisdefinition[GO:0007409]  
  • ISSOrtholog Curator
Behavioral response to cocainedefinition[GO:0048148]  
  • ISSOrtholog Curator
Behavioral response to ethanoldefinition[GO:0048149]  
  • ISSOrtholog Curator
Branching morphogenesis of a nervedefinition[GO:0048755]  
  • ISSOrtholog Curator
Isoform  Iso 2   Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • ICBHF-UCL
Cerebral cortex GABAergic interneuron migrationdefinition[GO:0021853]  
  • ISSOrtholog Curator
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Dopamine metabolic processdefinition[GO:0042417]  
1
  • ICBHF-UCL
Feeding behaviordefinition[GO:0007631] silver  
  • IEAOrtholog Compara
G-protein coupled receptor internalizationdefinition[GO:0002031] silver  
  • IEAOrtholog Compara
Grooming behaviordefinition[GO:0007625] silver  
  • IEAOrtholog Compara
Isoforms  Iso 1 and Iso 2   Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDABHF-UCL
Locomotory behaviordefinition[GO:0007626]  
  • ISSOrtholog Curator
Long-term memorydefinition[GO:0007616] silver  
  • IEAOrtholog Compara
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • IDABHF-UCL
  • IEAOrtholog Compara
Negative regulation of blood pressuredefinition[GO:0045776]  
  • ISSOrtholog Curator
Negative regulation of cell migrationdefinition[GO:0030336]  
  • ISSOrtholog Curator
Negative regulation of cell proliferationdefinition[GO:0008285]  
  • ISSOrtholog Curator
Negative regulation of circadian sleep/wake cycle, sleepdefinition[GO:0042321] silver  
  • IEAOrtholog Compara
Negative regulation of cytosolic calcium ion concentrationdefinition[GO:0051481] silver  
  • IEAOrtholog Compara
Negative regulation of dopamine receptor signaling pathwaydefinition[GO:0060160]  
  • ISSOrtholog Curator
Negative regulation of dopamine secretiondefinition[GO:0033602] silver  
  • IEAOrtholog Compara
Negative regulation of insulin secretiondefinition[GO:0046676] silver  
  • IEAOrtholog Compara
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
  • ISSOrtholog Curator
Negative regulation of protein secretiondefinition[GO:0050709]  
1
  • IDABHF-UCL
Negative regulation of synaptic transmission, glutamatergicdefinition[GO:0051967]  
  • ISSOrtholog Curator
Negative regulation of voltage-gated calcium channel activitydefinition[GO:1901386]  
1
  • IDABHF-UCL
  • IEAOrtholog Compara
Neurological system process involved in regulation of systemic arterial blood pressuredefinition[GO:0001976]  
  • ISSOrtholog Curator
Neuron-neuron synaptic transmissiondefinition[GO:0007270]  
  • ISSOrtholog Curator
Orbitofrontal cortex developmentdefinition[GO:0021769] silver  
  • IEAOrtholog Compara
Peristalsisdefinition[GO:0030432]  
  • ISSOrtholog Curator
Phosphatidylinositol metabolic processdefinition[GO:0046488]  
  • ISSOrtholog Curator
Phospholipase C-activating dopamine receptor signaling pathwaydefinition[GO:0060158]  
1
  • IGIMGI
Pigmentationdefinition[GO:0043473] silver  
  • IEAOrtholog Compara
Positive regulation of cytokinesisdefinition[GO:0032467]  
1
  • IMPUniProtKB
Isoforms  Iso 1 and Iso 2   Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482]  
1
  • IDABHF-UCL
Positive regulation of dopamine uptake involved in synaptic transmissiondefinition[GO:0051586]  
  • ISSOrtholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
  • IEAOrtholog Compara
Positive regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0045745] silver  
  • IEAOrtholog Compara
Positive regulation of growth hormone secretiondefinition[GO:0060124]  
  • ISSOrtholog Curator
Positive regulation of long-term synaptic potentiationdefinition[GO:1900273] silver  
  • IEAOrtholog Compara
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
  • IEAOrtholog Compara
Positive regulation of neuroblast proliferationdefinition[GO:0002052]  
  • ISSOrtholog Curator
Positive regulation of receptor internalizationdefinition[GO:0002092] silver  
  • IEAOrtholog Compara
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of urine volumedefinition[GO:0035810] silver  
  • IEAOrtholog Compara
Prepulse inhibitiondefinition[GO:0060134]  
  • ISSOrtholog Curator
Protein localizationdefinition[GO:0008104]  
  • ISSOrtholog Curator
Regulation of cAMP metabolic processdefinition[GO:0030814]  
1
  • IDABHF-UCL
Regulation of dopamine uptake involved in synaptic transmissiondefinition[GO:0051584]  
1
  • ICBHF-UCL
Regulation of heart ratedefinition[GO:0002027]  
  • ISSOrtholog Curator
Regulation of locomotion involved in locomotory behaviordefinition[GO:0090325] silver  
  • IEAOrtholog Compara
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169]  
  • ISSOrtholog Curator
Regulation of phosphoprotein phosphatase activitydefinition[GO:0043666] silver  
  • IEAOrtholog Compara
Regulation of potassium ion transportdefinition[GO:0043266]  
  • ISSOrtholog Curator
Regulation of sodium ion transportdefinition[GO:0002028]  
  • ISSOrtholog Curator
Regulation of synapse structural plasticitydefinition[GO:0051823] silver  
  • IEAOrtholog Compara
Regulation of synaptic transmission, GABAergicdefinition[GO:0032228]  
  • ISSOrtholog Curator
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
  • ISSOrtholog Curator
Response to amphetaminedefinition[GO:0001975]  
  • ISSOrtholog Curator
Response to axon injurydefinition[GO:0048678] silver  
  • IEAOrtholog Compara
Response to cocainedefinition[GO:0042220]  
  • ISSOrtholog Curator
Response to drugdefinition[GO:0042493]  
  • ISSOrtholog Curator
Response to histaminedefinition[GO:0034776]  
1
  • IDABHF-UCL
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to inactivitydefinition[GO:0014854] silver  
  • IEAOrtholog Compara
Response to iron iondefinition[GO:0010039] silver  
  • IEAOrtholog Compara
Response to light stimulusdefinition[GO:0009416]  
  • ISSOrtholog Curator
Response to morphinedefinition[GO:0043278]  
  • ISSOrtholog Curator
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Sensory perception of smelldefinition[GO:0007608]  
  • ISSOrtholog Curator
Striatum developmentdefinition[GO:0021756] silver  
  • IEAOrtholog Compara
Synapse assemblydefinition[GO:0007416]  
  • ISSOrtholog Curator
Synaptic transmission, dopaminergicdefinition[GO:0001963] silver  
  • IEAOrtholog Compara
Temperature homeostasisdefinition[GO:0001659]  
  • ISSOrtholog Curator
Visual learningdefinition[GO:0008542]  
  • ISSOrtholog Curator
Wnt signaling pathwaydefinition[GO:0016055] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+1813  
Gap junction  hsa04540+1813  
Neuroactive ligand-receptor interaction  hsa04080+1813  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Dopamine_receptor_D2
GenomeRNAi: 1813
PRO: PR:P14416
Chemistry
GuidetoPHARMACOLOGY: 215