DRD2 - D(2) dopamine receptor - human protein (Sequence)
 
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Protein
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DRD2 »  D(2) dopamine receptor
 
Protein also known as:  Dopamine D2 receptor.
Gene name:  DRD2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 467 3
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   443 aaMass: 50619 Da,  pI: 9.55
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
Domain 
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Disulfide bond  definition   [KW-1015]
Glycoprotein  definition   [KW-0325]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
InterPro: IPR000929 [ Dopamine rcpt ]
InterPro: IPR000276 [ GPCR Rhodpsn ]
InterPro: IPR017452 [ GPCR Rhodpsn 7TM ]
InterPro: IPR001922 [ Dopamine D2 rcpt ]
InterPro: IPR002233 [ ADR fam ]
PANTHER: PTHR24248:SF13 [ PTHR24248:SF13 ]
PANTHER: PTHR24248 [ PTHR24248 ]
Pfam: PF00001 [ 7tm 1 ]
PRINTS: PR00567 [ DOPAMINED2R ]
PRINTS: PR00237 [ GPCRRHODOPSN ]
PRINTS: PR00242 [ DOPAMINER ]
PROSITE: PS50262 [ G PROTEIN RECEP F1 2 ]
PROSITE: PS00237 [ G PROTEIN RECEP F1 1 ]
Genome annotation databases
Ensembl: Transcript: ENST00000346454;  Protein: ENSP00000278597;  Gene: ENSG00000149295.
Ensembl: Transcript: ENST00000362072;  Protein: ENSP00000354859;  Gene: ENSG00000149295.
Ensembl: Transcript: ENST00000355319;  Protein: ENSP00000347474;  Gene: ENSG00000149295.
Ensembl: Transcript: ENST00000544518;  Protein: ENSP00000441068;  Gene: ENSG00000149295.
Ensembl: Transcript: ENST00000542968;  Protein: ENSP00000442172;  Gene: ENSG00000149295.
Ensembl: Transcript: ENST00000538967;  Protein: ENSP00000438215;  Gene: ENSG00000149295.
Ensembl: Transcript: ENST00000543292;  Protein: ENSP00000438419;  Gene: ENSG00000149295.
Ensembl: Transcript: ENST00000542616;  Protein: ENSP00000441474;  Gene: ENSG00000149295.
KEGG: hsa:1813
UCSC: uc001pnz.3
Organism-specific databases
MGI: MGI:94924 [ Drd2 ]
Other
EvolutionaryTrace: P14416
PTM databases
PhosphoSite: P14416
Phylogenomic databases
eggNOG: NOG309657
HOVERGEN: HBG106962
KO: K04145
OMA: NSVKHSR
OrthoDB: EOG769ZMG
Sequence databases
CCDS: CCDS8361.1 [ P14416-1 ]
CCDS: CCDS8362.1 [ P14416-2 ]
EMBL: mRNA:  X51362 . Translation:  CAA35746.1 .
EMBL: mRNA:  M29066 . Translation:  AAA52761.1 .
EMBL: mRNA:  X51645 . Translation:  CAB56463.1 .
EMBL: Genomic DNA:  AB065860 . Translation:  BAC06078.1 .
EMBL: mRNA:  AF176812 . Translation:  AAF61479.1 .
EMBL: Genomic DNA:  AF050737 . Translation:  AAC78779.1 .
EMBL: mRNA:  BC021195 . Translation:  AAH21195.1 .
EMBL: mRNA:  S62137 . Translation:  AAB26819.1 .
EMBL: Genomic DNA:  X51646 . Translation:  CAB37869.1 .
EMBL: mRNA:  S69899 . Translation:  AAB20571.1 .
EMBL: Genomic DNA:  S58577 , S58584 , S58586 , S58588 , S58589 . Translation:  AAB26274.1 .
EMBL: mRNA:  M30625 . Translation:  AAA88024.1 .
IPI: IPI00219367
IPI: IPI00026590
IPI: IPI00375079
PIR: S08417
RefSeq: Protein:  NP_057658.2. Nucleotide sequence:  NM_016574.3.
RefSeq: Protein:  XP_005271482.1. Nucleotide sequence:  XM_005271425.1.
RefSeq: Protein:  NP_000786.1. Nucleotide sequence:  NM_000795.3.
UniProtKB: P14416 [ DRD2 ]
Protocols and materials databases
DNASU: 1813