AKR1A1 - Alcohol dehydrogenase [NADP(+)] - human protein (Function)
 
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AKR1A1 »  Alcohol dehydrogenase [NADP(+)]   [ EC 1.1.1.2 ]
 
Protein also known as:  Aldo-keto reductase family 1 member A1.
Gene name:  AKR1A1
Family name: Aldo/keto reductase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 1
GENE REF ISO

Function

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Overview 
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).  
3
  • CuratedUniProtKB
GO molecular function 
Alditol:NADP+ 1-oxidoreductase activitydefinition[GO:0004032]  
1
  • TASPINC
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
L-glucuronate reductase activitydefinition[GO:0047939] silver  
  • IEAOrtholog Compara
GO biological process 
Aldehyde catabolic processdefinition[GO:0046185] silver  
  • IEAOrtholog Compara
Cellular aldehyde metabolic processdefinition[GO:0006081]  
1
  • TASPINC
D-glucuronate catabolic processdefinition[GO:0042840] silver  
  • IEAOrtholog Compara
Glucose metabolic processdefinition[GO:0006006]  
1
  • TASPINC
L-ascorbic acid biosynthetic processdefinition[GO:0019853] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.2: An alcohol + NADP(+) an aldehyde + NADPH.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycerolipid metabolism  hsa00561+10327  
Glycolysis / Gluconeogenesis  hsa00010+10327  
Metabolic pathways  hsa01100+10327  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P14550
Other
GeneWiki: Aldo-keto_reductase_family_1,_member_A1
GenomeRNAi: 10327
PRO: PR:P14550