INSRR - Insulin receptor-related protein - human protein (Function)
 
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INSRR »  Insulin receptor-related protein   [ EC 2.7.10.1 ]  (IRR)
 
Protein also known as:  IR-related receptor. Cleaved into:  Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain.
Gene name:  INSRR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Insulin receptor substrate bindingdefinition[GO:0043560] silver  
  • IEAInterPro 2 GO
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548] silver  
  • IEAInterPro 2 GO
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
2
  • IDAUniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • IDAUniProtKB
Cellular response to alkaline pHdefinition[GO:0071469]  
1
  • IDAUniProtKB
Male sex determinationdefinition[GO:0030238] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • IDAGOC
  • IEAEC 2 GO
  • IEAInterPro 2 GO
  • IEAUniProtKB KW
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IMPUniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Prostate cancer  hsa05215+3645  
Regulation of actin cytoskeleton  hsa04810+3645  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: INSRR
GenomeRNAi: 3645
PRO: PR:P14616
Chemistry
GuidetoPHARMACOLOGY: 1802