SLC2A4 - Solute carrier family 2, facilitated glucose transporter member 4 - human protein (Function)
 
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SLC2A4 »  Solute carrier family 2, facilitated glucose transporter member 4
 
Protein also known as:  Glucose transporter type 4, insulin-responsive (GLUT-4).
Gene name:  SLC2A4
Entry whose protein(s) existence is based on evidence at protein level
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1 123 1
GENE REF ISO

Function

 show evidences
Overview 
Insulin-regulated facilitative glucose transporter.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.1.80  
GO molecular function 
D-glucose transmembrane transporter activitydefinition[GO:0055056] silver  
  • IEAOrtholog Compara
Glucose transmembrane transporter activitydefinition[GO:0005355]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Amylopectin biosynthetic processdefinition[GO:0010021] silver  
  • IEAOrtholog Compara
Brown fat cell differentiationdefinition[GO:0050873] silver  
  • IEAOrtholog Compara
Cellular response to insulin stimulusdefinition[GO:0032869]  
1
  • IDAUniProtKB
Cellular response to osmotic stressdefinition[GO:0071470] silver  
  • IEAOrtholog Compara
Glucose homeostasisdefinition[GO:0042593]  
2
  • IDABHF-UCL
  • IDAMGI
Glucose importdefinition[GO:0046323]  
1
  • NASBHF-UCL
Glucose transportdefinition[GO:0015758]  
1
  • TASUniProtKB
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+6517  
Insulin signaling pathway  hsa04910+6517  
Type II diabetes mellitus  hsa04930+6517  
According to Reactome, this protein belongs to the following pathways:
Facilitative Na+-independent glucose transporters  REACT_19343  
Glucose transport  REACT_212  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
Translocation of GLUT4 to the plasma membrane  REACT_147867  
Note 
Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation (By similarity).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Sugar transport  definition   [KW-0762]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GLUT4
GenomeRNAi: 6517
PRO: PR:P14672
Chemistry
GuidetoPHARMACOLOGY: 878