TYR - Tyrosinase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
TYR »  Tyrosinase   [ EC 1.14.18.1 ]
 
Protein also known as:  Tumor rejection antigen AB.
Gene name:  TYR
Family name: Tyrosinase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 138 2
GENE REF ISO

Function

 show evidences
Overview 
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.  
  • CuratedUniProtKB
GO molecular function 
Copper ion bindingdefinition[GO:0005507]  
1
  • IMPUniProtKB
Monophenol monooxygenase activitydefinition[GO:0004503]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
GO biological process 
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Eye pigment biosynthetic processdefinition[GO:0006726]  
1
  • TASPINC
Melanin biosynthetic process from tyrosinedefinition[GO:0006583]  
1
  • TASPINC
Thymus developmentdefinition[GO:0048538] silver  
  • IEAOrtholog Compara
Visual perceptiondefinition[GO:0007601]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
2 L-dopa + O(2) 2 dopaquinone + 2 H(2)O.  
  • CuratedUniProtKB
L-tyrosine + O(2) dopaquinone + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 copper ions per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Melanogenesis  hsa04916+7299  
Metabolic pathways  hsa01100+7299  
Riboflavin metabolism  hsa00740+7299  
Tyrosine metabolism  hsa00350+7299  
 
More information is available from:
 

Keywords

Biological process 
Melanin biosynthesis  definition   [KW-0470]
Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Tumor antigen  definition   [KW-0825]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Tyrosinase
GenomeRNAi: 7299
PRO: PR:P14679
Chemistry
GuidetoPHARMACOLOGY: 2643