IDE - Insulin-degrading enzyme - human protein (Function)
 
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IDE »  Insulin-degrading enzyme   [ EC 3.4.24.56 ]
 
Protein also known as:  Abeta-degrading protease.
Gene name:  IDE
Family name: Peptidase M16
Entry whose protein(s) existence is based on evidence at protein level
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1 109 2
GENE REF ISO

Function

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Overview 
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
ATPase activitydefinition[GO:0016887] silver  
  • IEAOrtholog Compara
Beta-amyloid bindingdefinition[GO:0001540] silver  
  • IEAOrtholog Compara
Beta-endorphin bindingdefinition[GO:0031626] silver  
  • IEAOrtholog Compara
Glycoprotein bindingdefinition[GO:0001948]  
1
  • IPIUniProtKB
Insulin bindingdefinition[GO:0043559]  
2
  • IPIUniProtKB
Metalloendopeptidase activitydefinition[GO:0004222]  
2
  • IDAUniProtKB
Peptide bindingdefinition[GO:0042277]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Ubiquitin bindingdefinition[GO:0043130]  
1
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200] silver  
  • IEAOrtholog Compara
Beta-amyloid metabolic processdefinition[GO:0050435]  
2
  • IDAUniProtKB
Bradykinin catabolic processdefinition[GO:0010815]  
2
  • IDAUniProtKB
Determination of adult lifespandefinition[GO:0008340]  
1
  • IDAUniProtKB
Hormone catabolic processdefinition[GO:0042447] silver  
  • IEAOrtholog Compara
Insulin catabolic processdefinition[GO:1901143]  
2
  • IDAUniProtKB
Insulin metabolic processdefinition[GO:1901142]  
1
  • IDAUniProtKB
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • NASUniProtKB
Negative regulation of proteolysisdefinition[GO:0045861] silver  
  • IEAOrtholog Compara
Positive regulation of protein oligomerizationdefinition[GO:0032461]  
1
  • IDAUniProtKB
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Protein homooligomerizationdefinition[GO:0051260]  
1
  • IDAUniProtKB
Protein homotetramerizationdefinition[GO:0051289] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
2
  • IDAUniProtKB
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • IDAUniProtKB
Ubiquitin homeostasisdefinition[GO:0010992]  
1
  • IDAUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.56: Degradation of insulin, glucagon and other polypeptides. No action on proteins.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activated by small peptides (By similarity). Activated by ATP and GTP, and to a lesser extent by CTP, TTP and PPPi. Inhibited by bacitracin. Inhibited by S-nitrosylation and oxidation agents.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Alzheimer's disease  hsa05010+3416  
Note 
ATP-binding induces a conformation change.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Insulin-degrading_enzyme
GenomeRNAi: 3416
PRO: PR:P14735