GP9 - Platelet glycoprotein IX - human protein (Function)
 
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GP9 »  Platelet glycoprotein IX  (GPIX)
 
Protein also known as:  Glycoprotein 9; CD antigen CD42a.
Gene name:  GP9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.  
  • CuratedUniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
ECM-receptor interaction  hsa04512+2815  
Hematopoietic cell lineage  hsa04640+2815  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
Note 
Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Blood coagulation  definition   [KW-0094]
Cell adhesion  definition   [KW-0130]
Hemostasis  definition   [KW-0356]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Glycoprotein_IX
GenomeRNAi: 2815
PRO: PR:P14770