MMP9 - Matrix metalloproteinase-9 - human protein (Function)
 
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MMP9 »  Matrix metalloproteinase-9   [ EC 3.4.24.35 ]  (MMP-9)
 
Protein also known as:  92 kDa type IV collagenase. Cleaved into:  67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9.
Gene name:  MMP9
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 1638 1
GENE REF ISO

Function

 show evidences
Overview 
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.  
2
  • UniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • UniProtKB
Endopeptidase activitydefinition[GO:0004175]  
1
  • ParkinsonsUK-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Metalloendopeptidase activitydefinition[GO:0004222]  
4
  • UniProtKB
  • MGI
Metallopeptidase activitydefinition[GO:0008237]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • UniProtKB
GO biological process 
Embryo implantationdefinition[GO:0007566] silver  
1
  • Ortholog Compara
Endodermal cell differentiationdefinition[GO:0035987]  
1
  • UniProtKB
Leukocyte migrationdefinition[GO:0050900] silver  
1
  • InterPro 2 GO
Macrophage differentiationdefinition[GO:0030225]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • CACAO
Negative regulation of cation channel activitydefinition[GO:2001258]  
1
  • UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:2001268] silver  
1
  • CACAO
Negative regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001243] silver  
1
  • CACAO
Ossificationdefinition[GO:0001503] silver  
1
  • InterPro 2 GO
Positive regulation of DNA bindingdefinition[GO:0043388] silver  
1
  • CACAO
Positive regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0045742] silver  
1
  • CACAO
Positive regulation of keratinocyte migrationdefinition[GO:0051549]  
1
  • BHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
1
  • CACAO
Positive regulation of receptor bindingdefinition[GO:1900122]  
1
  • UniProtKB
Positive regulation of release of cytochrome c from mitochondriadefinition[GO:0090200] silver  
1
  • CACAO
Proteolysisdefinition[GO:0006508]  
4
  • UniProtKB
  • ParkinsonsUK-UCL
Skeletal system developmentdefinition[GO:0001501] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.35: Cleavage of gelatin types I and V and collagen types IV and V.  
2
  • UniProtKB
It requires the following cofactors
 Zn(2+) : Binds 2 Zn(2+) ions per subunit.  
1
  • UniProtKB
 Ca(2+) : Binds 3 Ca(2+) ions per subunit.  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.  
3
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bladder cancer  hsa05219+4318  
Leukocyte transendothelial migration  hsa04670+4318  
Pathways in cancer  hsa05200+4318  
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Collagen degradation  REACT_150401  
Degradation of the extracellular matrix  REACT_118572  
EPH-ephrin mediated repulsion of cells  REACT_264198  
Signaling by SCF-KIT  REACT_111040  
Note 
In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.  
1
  • UniProtKB
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MMP9
GenomeRNAi: 4318
PRO: PR:P14780
Chemistry
GuidetoPHARMACOLOGY: 1633