IL2RB - Interleukin-2 receptor subunit beta - human protein (Function)
 
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Protein
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IL2RB »  Interleukin-2 receptor subunit beta
 
Protein also known as:  CD antigen CD122.
Gene name:  IL2RB
Entry whose protein(s) existence is based on evidence at protein level
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1 68 1
GENE REF ISO

Function

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Overview 
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.  
  • CuratedUniProtKB
GO molecular function 
Interleukin-2 bindingdefinition[GO:0019976]  
  • ISSOrtholog Curator
Contributes to interleukin-2 receptor activitydefinition[GO:0004911]  
2
  • IDAMGI
  • TASUniProtKB
GO biological process 
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • IDAMGI
Interleukin-2-mediated signaling pathwaydefinition[GO:0038110]  
2
  • IDAGOC
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAMGI
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3560  
Endocytosis  hsa04144+3560  
HTLV-I infection  hsa05166+3560  
Jak-STAT signaling pathway  hsa04630+3560  
Measles  hsa05162+3560  
According to Reactome, this protein belongs to the following pathways:
Interleukin receptor SHC signaling  REACT_23891  
Interleukin-2 signaling  REACT_27283  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IL2RB
GenomeRNAi: 3560
PRO: PR:P14784