IL2RB - Interleukin-2 receptor subunit beta - human protein (Sequence)
 
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IL2RB »  Interleukin-2 receptor subunit beta  (IL-2RB)
 
Protein also known as:  High affinity IL-2 receptor subunit beta; CD antigen CD122.
Gene name:  IL2RB
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 58 1
GENE REF ISO

Displayed isoform: Iso 1

 
 
Isoform Iso 1   551 aaMass: 61117 Da,  pI: 4.93
MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ DGALQDTSCQ VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT VDIVTLRVLC REGVRWRVMA IQDFKPFENL RLMAPISLQV VHVETHRCNI SWEISQASHY FERHLEFEAR TLSPGHTWEE APLLTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS SNHSLTSCFT NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP TGSSPQPLQP LSGEDDAYCT FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP DLVDFQPPPE LVLREAGEEV PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ ELQGQDPTHL V

Sequence

 show evidences
Domain 
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.  
  • CuratedUniProtKB
The box 1 motif is required for JAK interaction and/or activation.  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Polymorphism  definition   [KW-0621]
Domain 
Signal  definition   [KW-0732]
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Disulfide bond  definition   [KW-1015]
Glycoprotein  definition   [KW-0325]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 2.60.40.10
InterPro: IPR013783 [ Ig-like fold ]
InterPro: IPR003961 [ Fibronectin type3 ]
InterPro: IPR003531 [ Hempt rcpt S F1 CS ]
PROSITE: PS01355 [ HEMATOPO REC S F1 ]
PROSITE: PS50853 [ FN3 ]
SMART: SM00060 [ FN3 ]
SUPFAM: SSF49265 [ SSF49265 ]
Genome annotation databases
Ensembl: Transcript: ENST00000216223;  Protein: ENSP00000216223;  Gene: ENSG00000100385.
Ensembl: Transcript: ENST00000445595;  Protein: ENSP00000401020;  Gene: ENSG00000100385.
Ensembl: Transcript: ENST00000453962;  Protein: ENSP00000403731;  Gene: ENSG00000100385.
Ensembl: Transcript: ENST00000429622;  Protein: ENSP00000402685;  Gene: ENSG00000100385.
Ensembl: Transcript: ENST00000440958;  Protein: ENSP00000400416;  Gene: ENSG00000100385.
KEGG: hsa:3560
UCSC: uc003aqv.1
Organism-specific databases
MGI: MGI:96550 [ Il2rb ]
Other
EvolutionaryTrace: P14784
PTM databases
PhosphoSite: P14784
Phylogenomic databases
eggNOG: NOG46659
HOGENOM: HOG000038003
HOVERGEN: HBG052110
KO: K05069
OMA: ACQVYFT
OrthoDB: EOG72RMZ6
PhylomeDB: P14784
Sequence databases
CCDS: CCDS13942.1 [ P14784-1 ]
EMBL: mRNA:  AK312860 . Translation:  BAG35712.1 .
EMBL: Genomic DNA:  CH471095 . Translation:  EAW60144.1 .
EMBL: mRNA:  M26062 . Translation:  AAA59143.1 .
EMBL: mRNA:  CR456506 . Translation:  CAG30392.1 .
EMBL: Genomic DNA:  AL022314 . Translation:  CAA18444.1 .
EMBL: mRNA:  BC025691 . Translation:  AAH25691.1 .
EMBL: Genomic DNA:  AF517934 . Translation:  AAM54040.1 .
IPI: IPI00878728
PIR: A30342
RefSeq: Protein:  NP_000869.1. Nucleotide sequence:  NM_000878.3.
RefSeq: Protein:  XP_005261656.1. Nucleotide sequence:  XM_005261599.1.
UniProtKB: P14784 [ IL2RB ]
Protocols and materials databases
DNASU: 3560