POU2F1 - POU domain, class 2, transcription factor 1 - human protein (Function)
 
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POU2F1 »  POU domain, class 2, transcription factor 1
 
Gene name:  POU2F1
Entry whose protein(s) existence is based on evidence at protein level
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1 127 6
GENE REF ISO

Function

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Overview 
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
3
  • IDAUniProtKB
  • IDAMGI
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • IDAMGI
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
RNA Polymerase III Abortive And Retractive Initiation  REACT_22339  
RNA Polymerase III Transcription Initiation From Type 3 Promoter  REACT_571  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: POU2F1
GenomeRNAi: 5451
PRO: PR:P14859