GABRA1 - Gamma-aminobutyric acid receptor subunit alpha-1 - human protein (Function)
 
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GABRA1 »  Gamma-aminobutyric acid receptor subunit alpha-1
 
Protein also known as:  GABA(A) receptor subunit alpha-1.
Gene name:  GABRA1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).  
1
  • UniProtKB
GO molecular function 
Chloride channel activitydefinition[GO:0005254]  
1
  • UniProtKB KW
Drug bindingdefinition[GO:0008144]  
1
  • Ortholog Curator
Extracellular ligand-gated ion channel activitydefinition[GO:0005230] silver  
1
  • InterPro 2 GO
Contributes to GABA receptor activitydefinition[GO:0016917]  
1
  • Ortholog Curator
GABA-A receptor activitydefinition[GO:0004890] silver  
1
  • InterPro 2 GO
GO biological process 
Cellular response to histaminedefinition[GO:0071420] silver  
1
  • Ortholog Compara
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • UniProtKB KW
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
1
  • InterPro 2 GO
Synaptic transmission, GABAergicdefinition[GO:0051932]  
1
  • Ortholog Curator
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+2554  
Neuroactive ligand-receptor interaction  hsa04080+2554  
According to Reactome, this protein belongs to the following pathways:
GABA A receptor activation  REACT_24987  
Ligand-gated ion channel transport  REACT_25387  
Orphan transporters  REACT_267716  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links