GABRA1 - Gamma-aminobutyric acid receptor subunit alpha-1 - human protein (Function)
 
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GABRA1 »  Gamma-aminobutyric acid receptor subunit alpha-1
 
Protein also known as:  GABA(A) receptor subunit alpha-1.
Gene name:  GABRA1
Entry whose protein(s) existence is based on evidence at protein level
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1 31 1
GENE REF ISO

Function

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Overview 
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.  
  • CuratedUniProtKB
GO molecular function 
Chloride channel activitydefinition[GO:0005254]  
  • IEAUniProtKB KW
Drug bindingdefinition[GO:0008144]  
  • ISSOrtholog Curator
Extracellular ligand-gated ion channel activitydefinition[GO:0005230] silver  
  • IEAInterPro 2 GO
Contributes to GABA receptor activitydefinition[GO:0016917]  
  • ISSOrtholog Curator
GABA-A receptor activitydefinition[GO:0004890] silver  
  • IEAInterPro 2 GO
GO biological process 
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
  • IEAInterPro 2 GO
Synaptic transmission, GABAergicdefinition[GO:0051932]  
  • ISSOrtholog Curator
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
GABAergic synapse  hsa04727+2554  
Neuroactive ligand-receptor interaction  hsa04080+2554  
According to Reactome, this protein belongs to the following pathways:
Neuronal System  REACT_13685  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links