DARS - Aspartate--tRNA ligase, cytoplasmic - human protein (Function)
 
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Protein
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References

 
DARS »  Aspartate--tRNA ligase, cytoplasmic   [ EC 6.1.1.12 ]
 
Protein also known as:  Cell proliferation-inducing gene 40 protein.
Gene name:  DARS
Entry whose protein(s) existence is based on evidence at protein level
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1 37 1
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.  
  • CuratedUniProtKB
GO molecular function 
Aminoacylase activitydefinition[GO:0004046]  
1
  • TASPINC
Aspartate-tRNA ligase activitydefinition[GO:0004815]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Aspartyl-tRNA aminoacylationdefinition[GO:0006422] silver  
  • IEAInterPro 2 GO
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Translationdefinition[GO:0006412]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.1.1.12: ATP + L-aspartate + tRNA(Asp) AMP + diphosphate + L-aspartyl-tRNA(Asp).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Aminoacyl-tRNA biosynthesis  hsa00970+1615  
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Aminoacyl-tRNA synthetase  definition   [KW-0030]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DARS_(gene)
GenomeRNAi: 1615
PRO: PR:P14868