BRAF - Serine/threonine-protein kinase B-raf - human protein (Function)
 
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BRAF »  Serine/threonine-protein kinase B-raf   [ EC 2.7.11.1 ]
 
Protein also known as:  v-Raf murine sarcoma viral oncogene homolog B1.
Gene name:  BRAF
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
3
  • IPIIntAct
MAP kinase kinase kinase activitydefinition[GO:0004709] silver  
  • IEAOrtholog Compara
Mitogen-activated protein kinase kinase bindingdefinition[GO:0031434] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
15
  • IPIIntAct
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein kinase activitydefinition[GO:0004672]  
1
  • IDABHF-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
Not  Small GTPase bindingdefinition[GO:0031267]  
1
  • IPIUniProtKB
GO biological process 
Cellular response to calcium iondefinition[GO:0071277]  
1
  • IDABHF-UCL
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Organ morphogenesisdefinition[GO:0009887]  
1
  • TASPINC
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IDABHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • IMPBHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • IDAUniProtKB
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDABHF-UCL
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to epidermal growth factordefinition[GO:0070849]  
1
  • IDABHF-UCL
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 zinc ions per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activity is increased by EGF and HGF.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+673  
Colorectal cancer  hsa05210+673  
Endometrial cancer  hsa05213+673  
ErbB signaling pathway  hsa04012+673  
Focal adhesion  hsa04510+673  
Glioma  hsa05214+673  
Hepatitis C  hsa05160+673  
Insulin signaling pathway  hsa04910+673  
Long-term depression  hsa04730+673  
Long-term potentiation  hsa04720+673  
MAPK signaling pathway  hsa04010+673  
mTOR signaling pathway  hsa04150+673  
Natural killer cell mediated cytotoxicity  hsa04650+673  
Neurotrophin signaling pathway  hsa04722+673  
Pancreatic cancer  hsa05212+673  
Pathways in cancer  hsa05200+673  
Progesterone-mediated oocyte maturation  hsa04914+673  
Regulation of actin cytoskeleton  hsa04810+673  
Renal cell carcinoma  hsa05211+673  
Vascular smooth muscle contraction  hsa04270+673  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Neuronal System  REACT_13685  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: BRAF_(gene)
GenomeRNAi: 673
PRO: PR:P15056
Chemistry
GuidetoPHARMACOLOGY: 1943