GLUL - Glutamine synthetase - human protein (Function)
 
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GLUL »  Glutamine synthetase   [ EC 6.3.1.2 ]  (GS)
 
Protein also known as:  Glutamate--ammonia ligase.
Gene name:  GLUL
Family name: Glutamine synthetase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Dynein light chain bindingdefinition[GO:0045503] silver  
  • IEAOrtholog Compara
Glutamate bindingdefinition[GO:0016595] silver  
  • IEAOrtholog Compara
Glutamate decarboxylase activitydefinition[GO:0004351]  
  • IEAEC 2 GO
Identical protein bindingdefinition[GO:0042802]  
3
  • IPIIntAct
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAOrtholog Compara
Manganese ion bindingdefinition[GO:0030145] silver  
  • IEAOrtholog Compara
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • IDAUniProtKB
Glutamate catabolic processdefinition[GO:0006538]  
1
  • TASBHF-UCL
Glutamine biosynthetic processdefinition[GO:0006542]  
1
  • TASBHF-UCL
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of insulin secretiondefinition[GO:0032024] silver  
  • IEAOrtholog Compara
Positive regulation of synaptic transmission, glutamatergicdefinition[GO:0051968] silver  
  • IEAOrtholog Compara
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 6.3.1.2: ATP + L-glutamate + NH(3) ADP + phosphate + L-glutamine.  
  • CuratedUniProtKB
EC 4.1.1.15: L-glutamate 4-aminobutanoate + CO(2).  
  • CuratedUniProtKB
It requires the following cofactors
Biotin (By similarity).  
  • CuratedUniProtKB
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+2752  
Arginine and proline metabolism  hsa00330+2752  
GABAergic synapse  hsa04727+2752  
Glutamatergic synapse  hsa04724+2752  
Metabolic pathways  hsa01100+2752  
Nitrogen metabolism  hsa00910+2752  
According to Reactome, this protein belongs to the following pathways:
Amino acid synthesis and interconversion (transamination)  REACT_238  
Astrocytic Glutamate-Glutamine Uptake And Metabolism  REACT_13639  
 
More information is available from:
 

Keywords

Molecular function 
Ligase  definition   [KW-0436]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P15104
Other
GenomeRNAi: 2752
PRO: PR:P15104