AKR1B1 - Aldose reductase - human protein (Function)
 
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AKR1B1 »  Aldose reductase   [ EC 1.1.1.21 ]  (AR)
 
Protein also known as:  Aldo-keto reductase family 1 member B1.
Gene name:  AKR1B1
Family name: Aldo/keto reductase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.  
1
  • UniProtKB
GO molecular function 
Alditol:NADP+ 1-oxidoreductase activitydefinition[GO:0004032]  
1
  • EC 2 GO
Aldo-keto reductase (NADP) activitydefinition[GO:0004033]  
1
  • UniProtKB
Electron carrier activitydefinition[GO:0009055]  
1
  • UniProtKB
Glyceraldehyde oxidoreductase activitydefinition[GO:0043795]  
1
  • UniProtKB
GO biological process 
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
1
  • Ortholog Compara
Cellular response to methylglyoxaldefinition[GO:0097238] silver  
1
  • Ortholog Compara
Cellular response to peptidedefinition[GO:1901653] silver  
1
  • Ortholog Compara
Daunorubicin metabolic processdefinition[GO:0044597]  
1
  • UniProtKB
Doxorubicin metabolic processdefinition[GO:0044598]  
1
  • UniProtKB
Inner medullary collecting duct developmentdefinition[GO:0072061] silver  
1
  • Ortholog Compara
Maternal process involved in female pregnancydefinition[GO:0060135] silver  
1
  • Ortholog Compara
Naphthalene metabolic processdefinition[GO:0018931] silver  
1
  • Ortholog Compara
Norepinephrine metabolic processdefinition[GO:0042415] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Positive regulation of JAK-STAT cascadedefinition[GO:0046427] silver  
1
  • Ortholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
1
  • Ortholog Compara
Response to stressdefinition[GO:0006950]  
1
  • UniProtKB
Response to thyroid hormonedefinition[GO:0097066] silver  
1
  • Ortholog Compara
Response to water deprivationdefinition[GO:0009414] silver  
1
  • Ortholog Compara
Sorbitol biosynthetic processdefinition[GO:0006061] silver  
1
  • Ortholog Compara
Stress-activated protein kinase signaling cascadedefinition[GO:0031098] silver  
1
  • Ortholog Compara
Tissue homeostasisdefinition[GO:0001894] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.21: Alditol + NAD(P)(+) aldose + NAD(P)H.  
1
  • UniProtKB
It is regulated in the following manner
Cys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fructose and mannose metabolism  hsa00051+231  
Galactose metabolism  hsa00052+231  
Glycerolipid metabolism  hsa00561+231  
Metabolic pathways  hsa01100+231  
Pentose and glucuronate interconversions  hsa00040+231  
Pyruvate metabolism  hsa00620+231  
According to Reactome, this protein belongs to the following pathways:
Fructose biosynthesis  R-HSA-5652227  
Pregnenolone biosynthesis  R-HSA-196108  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P15121
Other
GeneWiki: AKR1B1
GenomeRNAi: 231
PRO: PR:P15121
Chemistry
GuidetoPHARMACOLOGY: 2768