ANPEP - Aminopeptidase N - human protein (Function)
 
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ANPEP »  Aminopeptidase N   [ EC 3.4.11.2 ]  (AP-N)
 
Protein also known as:  Myeloid plasma membrane glycoprotein CD13; CD antigen CD13.
Gene name:  ANPEP
Family name: Peptidase M1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 118 1
GENE REF ISO

Function

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Overview 
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.  
9
  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
  • IEAUniProtKB KW
Metallopeptidase activitydefinition[GO:0008237]  
  • IEAUniProtKB KW
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Virus receptor activitydefinition[GO:0001618]  
  • IEAUniProtKB KW
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Response to virusdefinition[GO:0009615]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.11.2: Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glutathione metabolism  hsa00480+290  
Hematopoietic cell lineage  hsa04640+290  
Metabolic pathways  hsa01100+290  
Renin-angiotensin system  hsa04614+290  
According to Reactome, this protein belongs to the following pathway:
Metabolism of Angiotensinogen to Angiotensins  REACT_147707  
Note 
Found to serve as a receptor for tumor-homing peptides, more specifically NGR peptides. It could serve thus as a target for delivering drugs into tumors. Concentration in human hepatic bile, varies from 17.3 to 57.6 micrograms/ml.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Aminopeptidase  definition   [KW-0031]
Developmental protein  definition   [KW-0217]
Host cell receptor for virus entry  definition   [KW-1183]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P15144
Other
GeneWiki: Alanine_aminopeptidase
GenomeRNAi: 290
PRO: PR:P15144