PGAM2 - Phosphoglycerate mutase 2 - human protein (Function)
 
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PGAM2 »  Phosphoglycerate mutase 2   [ EC 3.1.3.13EC 5.4.2.11EC 5.4.2.4 ]
 
Protein also known as:  Muscle-specific phosphoglycerate mutase.
Gene name:  PGAM2
Entry whose protein(s) existence is based on evidence at protein level
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1 23 1
GENE REF ISO

Function

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Overview 
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.  
  • CuratedUniProtKB
GO molecular function 
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activitydefinition[GO:0046538] silver  
  • IEAOrtholog Compara
Bisphosphoglycerate 2-phosphatase activitydefinition[GO:0004083]  
  • IEAEC 2 GO
Bisphosphoglycerate mutase activitydefinition[GO:0004082]  
  • IEAEC 2 GO
Cofactor bindingdefinition[GO:0048037] silver  
  • IEAOrtholog Compara
Phosphoglycerate mutase activitydefinition[GO:0004619]  
1
  • IMPUniProtKB
GO biological process 
Glycolytic processdefinition[GO:0006096]  
1
  • IMPUniProtKB
Response to mercury iondefinition[GO:0046689] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Striated muscle contractiondefinition[GO:0006941]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 5.4.2.11: 2-phospho-D-glycerate 3-phospho-D-glycerate.  
  • CuratedUniProtKB
EC 5.4.2.4: 3-phospho-D-glyceroyl phosphate 2,3-bisphospho-D-glycerate.  
  • CuratedUniProtKB
EC 3.1.3.13: 2,3-bisphospho-D-glycerate + H(2)O 3-phospho-D-glycerate + phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycolysis / Gluconeogenesis  hsa00010+5224  
Metabolic pathways  hsa01100+5224  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Glycolysis  definition   [KW-0324]
Molecular function 
Hydrolase  definition   [KW-0378]
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 5224
PRO: PR:P15259