ARSA - Arylsulfatase A - human protein (Function)
 
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ARSA »  Arylsulfatase A   [ EC 3.1.6.8 ]  (ASA)
 
Protein also known as:  Cerebroside-sulfatase. Cleaved into:  Arylsulfatase A component B; Arylsulfatase A component C.
Gene name:  ARSA
Family name: Sulfatase
Entry whose protein(s) existence is based on evidence at protein level
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1 97 2
GENE REF ISO

Function

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Overview 
Hydrolyzes cerebroside sulfate.  
  • CuratedUniProtKB
GO molecular function 
Arylsulfatase activitydefinition[GO:0004065] silver  
  • IEAOrtholog Compara
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Sulfuric ester hydrolase activitydefinition[GO:0008484]  
1
  • IDAMGI
GO biological process 
Autophagydefinition[GO:0006914] silver  
  • IEAOrtholog Compara
Binding of sperm to zona pellucidadefinition[GO:0007339] silver  
  • IEAOrtholog Compara
Central nervous system developmentdefinition[GO:0007417] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to methylmercurydefinition[GO:0051597] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to pHdefinition[GO:0009268] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.6.8: A cerebroside 3-sulfate + H(2)O a cerebroside + sulfate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 calcium ion per subunit.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+410  
Sphingolipid metabolism  hsa00600+410  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Metabolism of proteins  REACT_17015  
Note 
The metal cofactor was first identified as magnesium ion, based on the structure of the recombinant protein, but when purified from human placenta, the protein contains 1 calcium ion per subunit.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Arylsulfatase_A
GenomeRNAi: 410
PRO: PR:P15289