ARSA - Arylsulfatase A - human protein (Function)
 
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ARSA »  Arylsulfatase A   [ EC 3.1.6.8 ]  (ASA)
 
Protein also known as:  Cerebroside-sulfatase. Cleaved into:  Arylsulfatase A component B; Arylsulfatase A component C.
Gene name:  ARSA
Family name: Sulfatase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Hydrolyzes cerebroside sulfate.  
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  • UniProtKB
GO molecular function 
Arylsulfatase activitydefinition[GO:0004065]  
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  • PINC
Calcium ion bindingdefinition[GO:0005509]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Sulfuric ester hydrolase activitydefinition[GO:0008484]  
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  • MGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.6.8: A cerebroside 3-sulfate + H(2)O a cerebroside + sulfate.  
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  • UniProtKB
It requires the following cofactor
 Ca(2+) : Binds 1 Ca(2+) ion per subunit.  
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  • UniProtKB
It is regulated in the following manner
Inhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine.  
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  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+410  
Sphingolipid metabolism  hsa00600+410  
According to Reactome, this protein belongs to the following pathways:
Glycosphingolipid metabolism  R-HSA-1660662  
The activation of arylsulfatases  R-HSA-1663150  
Note 
The metal cofactor was first identified as magnesium ion, based on the structure of the recombinant protein, but when purified from human placenta, the protein contains 1 calcium ion per subunit.  
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  • UniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Arylsulfatase_A
GenomeRNAi: 410
PRO: PR:P15289
Chemistry
SwissLipids: SLP:000000913