ACPP - Prostatic acid phosphatase - human protein (Function)
 
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ACPP »  Prostatic acid phosphatase   [ EC 3.1.3.2 ]  (PAP)
 
Protein also known as:  Thiamine monophosphatase (TMPase). Cleaved into:  PAPf39.
Gene name:  ACPP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.  
4
  • CuratedUniProtKB
GO molecular function 
5'-nucleotidase activitydefinition[GO:0008253]  
1
  • IDAUniProtKB
Acid phosphatase activitydefinition[GO:0003993]  
1
  • IMPUniProtKB
Choline bindingdefinition[GO:0033265] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Lysophosphatidic acid phosphatase activitydefinition[GO:0052642]  
1
  • IDAUniProtKB
Phosphatase activitydefinition[GO:0016791]  
2
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Thiamine phosphate phosphatase activitydefinition[GO:0042131]  
  • ISSOrtholog Curator
GO biological process 
Adenosine metabolic processdefinition[GO:0046085]  
1
  • IDAUniProtKB
Dephosphorylationdefinition[GO:0016311]  
1
  • IMPUniProtKB
Nucleotide metabolic processdefinition[GO:0009117] silver  
  • IEAOrtholog Compara
Positive regulation of adenosine receptor signaling pathwaydefinition[GO:0060168]  
2
  • IMPUniProtKB
Purine nucleobase metabolic processdefinition[GO:0006144] silver  
  • IEAOrtholog Compara
Regulation of sensory perception of paindefinition[GO:0051930]  
2
  • IMPUniProtKB
Thiamine metabolic processdefinition[GO:0006772]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.1.3.2: A phosphate monoester + H(2)O an alcohol + phosphate.  
1
  • CuratedUniProtKB
EC 3.1.3.5: A 5'-ribonucleotide + H(2)O a ribonucleoside + phosphate.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Phosphatase activity inhibited by L(+)-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Riboflavin metabolism  hsa00740+55  
Note 
Used as a diagnostic tool for staging metastatic prostatic cancer.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P15309
Other
GeneWiki: Prostatic_acid_phosphatase
GenomeRNAi: 55
PRO: PR:P15309