ATF2 - Cyclic AMP-dependent transcription factor ATF-2 - human protein (Function)
 
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ATF2 »  Cyclic AMP-dependent transcription factor ATF-2   [ EC 2.3.1.48 ]  (cAMP-dependent transcription factor ATF-2)
 
Protein also known as:  Cyclic AMP-responsive element-binding protein 2 (CREB-2).
Gene name:  ATF2
Family name: bZIP » ATF
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.  
4
  • CuratedUniProtKB
GO molecular function 
cAMP response element bindingdefinition[GO:0035497]  
1
  • IDABHF-UCL
cAMP response element binding protein bindingdefinition[GO:0008140]  
1
  • IDABHF-UCL
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Histone acetyltransferase activitydefinition[GO:0004402]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • IDABHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • ICBHF-UCL
RNA polymerase II transcription factor binding transcription factor activitydefinition[GO:0001076]  
1
  • ICBHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAMGI
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
2
  • IDAUniProtKB
Fat cell differentiationdefinition[GO:0045444] silver  
  • IEAOrtholog Compara
Histone acetylationdefinition[GO:0016573]  
1
  • IDAGOC
Intra-S DNA damage checkpointdefinition[GO:0031573]  
1
  • IMPUniProtKB
Outflow tract morphogenesisdefinition[GO:0003151] silver  
  • IEAOrtholog Compara
Positive regulation of mitochondrial membrane permeability involved in apoptotic processdefinition[GO:1902110]  
1
  • IMPUniProtKB
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IMPUniProtKB
Positive regulation of transforming growth factor beta2 productiondefinition[GO:0032915] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • ICBHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IMPUniProtKB
Response to osmotic stressdefinition[GO:0006970]  
1
  • IDAUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • ICGOC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+1386  
HTLV-I infection  hsa05166+1386  
Influenza A  hsa05164+1386  
MAPK signaling pathway  hsa04010+1386  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
TRAF6 Mediated Induction of proinflammatory cytokines  REACT_6782  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links