CD19 - B-lymphocyte antigen CD19 - human protein (Function)
 
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CD19 »  B-lymphocyte antigen CD19
 
Protein also known as:  B-lymphocyte surface antigen B4; CD antigen CD19.
Gene name:  CD19
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.  
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  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Receptor signaling protein activitydefinition[GO:0005057]  
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  • PINC
GO biological process 
B cell receptor signaling pathwaydefinition[GO:0050853] silver  
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  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
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  • PINC
Cellular defense responsedefinition[GO:0006968]  
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  • PINC
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281] silver  
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  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+930  
Hematopoietic cell lineage  hsa04640+930  
Primary immunodeficiency  hsa05340+930  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  R-HSA-983695  
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell  R-HSA-198933  
PIP3 activates AKT signaling  R-HSA-1257604  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD19
GenomeRNAi: 930
PRO: PR:P15391