FOSL2 - Fos-related antigen 2 - human protein (Function)
 
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Protein
Gene
References

 
FOSL2 »  Fos-related antigen 2  (FRA-2)
 
Gene name:  FOSL2
Family name: bZIP » Fos
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
GO biological process 
Cell deathdefinition[GO:0008219]  
1
  • TASPINC
Cellular response to hormone stimulusdefinition[GO:0032870] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to corticosteronedefinition[GO:0051412] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to morphinedefinition[GO:0043278] silver  
  • IEAOrtholog Compara
Response to progesteronedefinition[GO:0032570] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Osteoclast differentiation  hsa04380+2355  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOSL2
GenomeRNAi: 2355
PRO: PR:P15408