FOSL2 - Fos-related antigen 2 - human protein (Function)
 
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Protein
Gene
References

 
FOSL2 »  Fos-related antigen 2  (FRA-2)
 
Gene name:  FOSL2
Family name: bZIP » Fos
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.  
1
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • RefGenome
Transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0000982]  
1
  • RefGenome
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • PINC
GO biological process 
Cell deathdefinition[GO:0008219]  
1
  • PINC
Keratinocyte developmentdefinition[GO:0003334] silver  
1
  • Ortholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • PINC
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Osteoclast differentiation  hsa04380+2355  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOSL2
GenomeRNAi: 2355
PRO: PR:P15408