HPGD - 15-hydroxyprostaglandin dehydrogenase [NAD(+)] - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
HPGD »  15-hydroxyprostaglandin dehydrogenase [NAD(+)]
 
Gene name:  HPGD
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 73 5
GENE REF ISO

Function

 show evidences
Overview 
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.  
3
  • CuratedUniProtKB
GO molecular function 
15-hydroxyprostaglandin dehydrogenase (NAD+) activitydefinition[GO:0016404]  
5
  • IDAUniProtKB
Catalytic activitydefinition[GO:0003824]  
1
  • IDAUniProtKB
NAD bindingdefinition[GO:0051287]  
2
  • IDAUniProtKB
NAD+ bindingdefinition[GO:0070403]  
1
  • IDAUniProtKB
Prostaglandin E receptor activitydefinition[GO:0004957]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • TASUniProtKB
GO biological process 
Ductus arteriosus closuredefinition[GO:0097070]  
  • ISSOrtholog Curator
Female pregnancydefinition[GO:0007565]  
1
  • IDAUniProtKB
Lipoxygenase pathwaydefinition[GO:0019372]  
1
  • TASUniProtKB
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • IDAUniProtKB
Ovulationdefinition[GO:0030728]  
  • ISSOrtholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Parturitiondefinition[GO:0007567]  
1
  • IDAUniProtKB
Prostaglandin metabolic processdefinition[GO:0006693]  
1
  • IDAUniProtKB
Thrombin receptor signaling pathwaydefinition[GO:0070493]  
  • ISSOrtholog Curator
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.141: (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Synthesis of Lipoxins (LX)  REACT_150320  
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)  REACT_150149  
 

Biophysicochemical properties

Kinetic parameters
KM 38 uM for NAD
KM 3.4 uM for prostaglandin E2

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Prostaglandin metabolism  definition   [KW-0644]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P15428
Other
GeneWiki: HPGD
GenomeRNAi: 3248
PRO: PR:P15428