CSF2RA - Granulocyte-macrophage colony-stimulating factor receptor subunit alpha - human protein (Function)
 
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CSF2RA »  Granulocyte-macrophage colony-stimulating factor receptor subunit alpha  (GMR-alpha)
 
Protein also known as:  CDw116; CD antigen CD116.
Gene name:  CSF2RA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.  
  • CuratedUniProtKB
GO molecular function 
Cytokine receptor activitydefinition[GO:0004896] silver  
  • IEAInterPro 2 GO
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
GO biological process 
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+1438  
Hematopoietic cell lineage  hsa04640+1438  
Jak-STAT signaling pathway  hsa04630+1438  
Pathways in cancer  hsa05200+1438  
According to Reactome, this protein belongs to the following pathways:
Interleukin receptor SHC signaling  REACT_23891  
Interleukin-3, 5 and GM-CSF signaling  REACT_23837  
Note 
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 1438
PRO: PR:P15509
Chemistry
GuidetoPHARMACOLOGY: 1707