CSF2RA - Granulocyte-macrophage colony-stimulating factor receptor subunit alpha - human protein (Function)
 
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CSF2RA »  Granulocyte-macrophage colony-stimulating factor receptor subunit alpha  (GMR-alpha)
 
Protein also known as:  CDw116; CD antigen CD116.
Gene name:  CSF2RA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.  
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  • UniProtKB
GO molecular function 
Granulocyte colony-stimulating factor bindingdefinition[GO:0051916] silver  
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  • Ortholog Compara
Granulocyte colony-stimulating factor receptor activitydefinition[GO:0004902] silver  
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  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Receptor activitydefinition[GO:0004872]  
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  • PINC
GO biological process 
Cellular response to granulocyte macrophage colony-stimulating factor stimulusdefinition[GO:0097011] silver  
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  • Ortholog Compara
Granulocyte colony-stimulating factor signaling pathwaydefinition[GO:0038158] silver  
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  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+1438  
Hematopoietic cell lineage  hsa04640+1438  
Jak-STAT signaling pathway  hsa04630+1438  
Pathways in cancer  hsa05200+1438  
According to Reactome, this protein belongs to the following pathways:
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
GPVI-mediated activation cascade  R-HSA-114604  
Interleukin receptor SHC signaling  R-HSA-912526  
Interleukin-3, 5 and GM-CSF signaling  R-HSA-512988  
RAF/MAP kinase cascade  R-HSA-5673001  
Note 
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.  
1
  • UniProtKB
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 1438
PRO: PR:P15509
Chemistry
GuidetoPHARMACOLOGY: 1707