AREG - Amphiregulin - human protein (Function)
 
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AREG »  Amphiregulin  (AR)
 
Protein also known as:  Colorectum cell-derived growth factor (CRDGF).
Gene name:  AREG ; AREGB
Family name: Amphiregulin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.  
1
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
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  • UniProtKB KW
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
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  • RefGenome
Growth factor activitydefinition[GO:0008083] silver  
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  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
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  • IntAct
GO biological process 
Cell proliferationdefinition[GO:0008283]  
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  • PINC
Cell-cell signalingdefinition[GO:0007267]  
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  • PINC
Dichotomous subdivision of terminal units involved in mammary gland duct morphogenesisdefinition[GO:0060598] silver  
1
  • Ortholog Compara
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • BHF-UCL
Epithelial cell proliferation involved in mammary gland duct elongationdefinition[GO:0060750] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • BHF-UCL
Glial cell proliferationdefinition[GO:0014009] silver  
1
  • Ortholog Compara
Mammary gland alveolus developmentdefinition[GO:0060749] silver  
1
  • Ortholog Compara
Mammary gland branching involved in thelarchedefinition[GO:0060744] silver  
1
  • Ortholog Compara
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
1
  • Ortholog Compara
Neuron projection developmentdefinition[GO:0031175] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • RefGenome
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • BHF-UCL
Positive regulation of phosphorylationdefinition[GO:0042327] silver  
1
  • Ortholog Compara
Response to cAMPdefinition[GO:0051591] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
1
  • Ortholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
ErbB signaling pathway  hsa04012+374  
Note 
AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.  
1
  • UniProtKB
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Amphiregulin
GenomeRNAi: 374
PRO: PR:P15514