AREG - Amphiregulin - human protein (Function)
 
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AREG »  Amphiregulin  (AR)
 
Protein also known as:  Colorectum cell-derived growth factor (CRDGF).
Gene name:  AREG ; AREGB
Family name: Amphiregulin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • IDABHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
ErbB signaling pathway  hsa04012+374  
Note 
AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Amphiregulin
PRO: PR:P15514