CYP11B1 - Cytochrome P450 11B1, mitochondrial - human protein (Function)
 
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CYP11B1 »  Cytochrome P450 11B1, mitochondrial
 
Protein also known as:  Steroid 11-beta-hydroxylase [EC 1.14.15.4].
Gene name:  CYP11B1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 85 2
GENE REF ISO

Function

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Overview 
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.  
1
  • UniProtKB
GO molecular function 
Heme bindingdefinition[GO:0020037]  
1
  • BHF-UCL
Iron ion bindingdefinition[GO:0005506] silver  
1
  • InterPro 2 GO
Steroid 11-beta-monooxygenase activitydefinition[GO:0004507]  
3
  • BHF-UCL
GO biological process 
Aldosterone biosynthetic processdefinition[GO:0032342]  
2
  • UniProtKB
  • BHF-UCL
C21-steroid hormone biosynthetic processdefinition[GO:0006700]  
1
  • BHF-UCL
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • UniProtKB
Cellular response to potassium iondefinition[GO:0035865]  
1
  • UniProtKB
Cortisol biosynthetic processdefinition[GO:0034651]  
3
  • UniProtKB
  • BHF-UCL
Glucose homeostasisdefinition[GO:0042593]  
1
  • BHF-UCL
Immune responsedefinition[GO:0006955]  
1
  • BHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Regulation of blood pressuredefinition[GO:0008217]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.15.4: A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O.  
1
  • UniProtKB
It requires the following cofactor
 heme  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1584  
Steroid hormone biosynthesis  hsa00140+1584  
According to Reactome, this protein belongs to the following pathways:
Endogenous sterols  REACT_13812  
Glucocorticoid biosynthesis  REACT_11036  
 
More information is available from:
 

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Steroidogenesis  definition   [KW-0755]
Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Steroid_11-beta-hydroxylase
GenomeRNAi: 1584
PRO: PR:P15538
Chemistry
GuidetoPHARMACOLOGY: 1359