PHKG2 - Phosphorylase b kinase gamma catalytic chain, liver/testis isoform - human protein (Function)
 
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PHKG2 »  Phosphorylase b kinase gamma catalytic chain, liver/testis isoform   [ EC 2.7.11.19 ]  (PHK-gamma-T)
 
Protein also known as:  Phosphorylase kinase subunit gamma-2.
Gene name:  PHKG2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
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  • UniProtKB KW
Phosphorylase kinase activitydefinition[GO:0004689]  
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  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • UniProtKB
Tau-protein kinase activitydefinition[GO:0050321]  
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  • UniProtKB
GO biological process 
Generation of precursor metabolites and energydefinition[GO:0006091]  
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  • PINC
Glycogen biosynthetic processdefinition[GO:0005978] silver  
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  • InterPro 2 GO
Glycogen metabolic processdefinition[GO:0005977]  
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  • PINC
Positive regulation of glycogen catabolic processdefinition[GO:0045819]  
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  • UniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
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  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.19: 2 ATP + phosphorylase b 2 ADP + phosphorylase a.  
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  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5261  
Insulin signaling pathway  hsa04910+5261  
According to Reactome, this protein belongs to the following pathway:
Glycogen breakdown (glycogenolysis)  REACT_1008  
 
More information is available from:
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glycogen metabolism  definition   [KW-0321]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PHKG2
GenomeRNAi: 5261
PRO: PR:P15735
Chemistry
GuidetoPHARMACOLOGY: 2147