ARSB - Arylsulfatase B - human protein (Function)
 
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ARSB »  Arylsulfatase B   [ EC 3.1.6.12 ]  (ASB)
 
Protein also known as:  N-acetylgalactosamine-4-sulfatase (G4S).
Gene name:  ARSB
Family name: Sulfatase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 55 2
GENE REF ISO

Function

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GO molecular function 
Arylsulfatase activitydefinition[GO:0004065] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Autophagydefinition[GO:0006914] silver  
  • IEAOrtholog Compara
Central nervous system developmentdefinition[GO:0007417] silver  
  • IEAOrtholog Compara
Lysosomal transportdefinition[GO:0007041]  
1
  • TASPINC
Lysosome organizationdefinition[GO:0007040]  
1
  • TASPINC
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to methylmercurydefinition[GO:0051597] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to pHdefinition[GO:0009268] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.6.12: Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 calcium ion per subunit.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan degradation  hsa00531+411  
Lysosome  hsa04142+411  
Metabolic pathways  hsa01100+411  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
Metabolism of proteins  REACT_17015  
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 411
PRO: PR:P15848