ARSB - Arylsulfatase B - human protein (Function)
 
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ARSB »  Arylsulfatase B   [ EC 3.1.6.12 ]  (ASB)
 
Protein also known as:  N-acetylgalactosamine-4-sulfatase (G4S).
Gene name:  ARSB
Family name: Sulfatase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 63 2
GENE REF ISO

Function

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Overview 
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).  
3
  • UniProtKB
GO molecular function 
Arylsulfatase activitydefinition[GO:0004065] silver  
1
  • Ortholog Compara
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
N-acetylgalactosamine-4-sulfatase activitydefinition[GO:0003943]  
1
  • UniProtKB
GO biological process 
Autophagydefinition[GO:0006914] silver  
1
  • Ortholog Compara
Central nervous system developmentdefinition[GO:0007417] silver  
1
  • Ortholog Compara
Colon epithelial cell migrationdefinition[GO:0061580]  
1
  • UniProtKB
Lysosomal transportdefinition[GO:0007041]  
1
  • PINC
Lysosome organizationdefinition[GO:0007040]  
1
  • PINC
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
1
  • Ortholog Curator
Regulation of epithelial cell migrationdefinition[GO:0010632]  
1
  • UniProtKB
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to methylmercurydefinition[GO:0051597] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Response to pHdefinition[GO:0009268] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.6.12: Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.  
1
  • UniProtKB
It requires the following cofactor
 Ca(2+) : Binds 1 Ca(2+) ion per subunit.  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by ethanol (By similarity).  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan degradation  hsa00531+411  
Lysosome  hsa04142+411  
Metabolic pathways  hsa01100+411  
According to Reactome, this protein belongs to the following pathways:
CS/DS degradation  REACT_120888  
Glycosphingolipid metabolism  REACT_116105  
MPS VI - Maroteaux-Lamy syndrome  REACT_147719  
The activation of arylsulfatases  REACT_121036  
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 411
PRO: PR:P15848