CHN1 - N-chimaerin - human protein (Function)
 
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Protein
Gene
References

 
CHN1 »  N-chimaerin
 
Protein also known as:  Rho GTPase-activating protein 2.
Gene name:  CHN1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.  
1
  • UniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875] silver  
1
  • Ortholog Compara
GTPase activator activitydefinition[GO:0005096]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • PINC
GO biological process 
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
1
  • Ortholog Curator
Motor neuron axon guidancedefinition[GO:0008045]  
1
  • Ortholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • UniProtKB KW
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • GOC
Regulation of axonogenesisdefinition[GO:0050770]  
1
  • Ortholog Curator
Regulation of Rac GTPase activitydefinition[GO:0032314] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Rho GTPase cycle  REACT_11051  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1123
PRO: PR:P15882